BACKGROUND Intrathecal lidocaine hydrochloride under general anesthesia has been used as an alternative method of euthanasia in equids. Carnivore, scavenger, and even human consumption of horse meat from carcasses have been anecdotally reported in rural areas after this method of euthanasia. The presence of drug residues in horse meat has not been investigated. HYPOTHESIS/OBJECTIVES To invest...

PURPOSE We describe a case of transient visual loss following cataract surgery with unpreserved intracameral lidocaine. METHOD A 50-year-old man with posterior polar cataract underwent phacoemulsification. Following capsulorhexis and hydrodelineation with 0.5 cc of unpreserved lidocaine 1%, a portion of fluid reached behind the crystalline lens and caused the posterior capsule rupture. Catara...

thetic agent in pediatric practice, with the well-known benefits of smooth induction characteristics, antiemetic effect, rapid recovery and pleasant emergence. The drug appears to have a wide margin of safety and is less likely to cause significant hypotension than in the elderly population. With the exception of concerns that have been raised with its use for long-term sedation in the pediatri...

background: morphine and lidocaine are known to influence the perception of pain. the present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (mnd), morphine dependent (md) and morphine withdrawal (mw) animals. methods: adult male wistar rats were divided into four groups: control, mnd, md and mw rats. lidocain...

BACKGROUND The lidocaine derivative, QX-314, produces long-lasting regional anesthesia in various animal models. We designed this study to examine whether QX-314 could produce long-lasting intravenous regional anesthesia (IVRA) in a rat model. METHODS IVRA was performed on tail of rats. EC50 (median effective concentration) of QX-314 in IVRA was determined by up-and-down method. IVRA on tail ...

BACKGROUND Intravenous lipid emulsion has been used to treat systemic toxicity of local anesthetics. The goals of this in vitro study were to determine the ability of two lipid emulsions (Intralipid® and Lipofundin® MCT/LCT) to reverse toxic dose local anesthetic-induced vasodilation in isolated rat aortas. METHODS Isolated endothelium-denuded aortas were suspended for isometric tension recor...