intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. in this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with lidocaine following perineal operation. forty patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5% heav...

OBJECTIVE To determine whether pretreatment of skin with erbium:YAG (Er:YAG) laser-assisted delivery facilitates the penetration of lidocaine cream to provide anesthesia suitable for needlesticks after just 5 minutes. DESIGN Trial 1 was a double-blind randomized controlled trial, whereas trial 2 was a nonblinded randomized controlled trial. SETTING The study was conducted in 2 facilities, a...

STUDY OBJECTIVE The study aims to evaluate the efficacy and safety of intranasal lidocaine administration for migraine treatment. METHODS This single-center, double-blind, randomized, controlled trial was conducted in a tertiary care emergency department. Included patients met the migraine criteria of the International Headache Society. Patients were randomized to intranasal lidocaine or sali...

BACKGROUND AND PURPOSE Cognitive decline after cardiac surgery remains common and diminishes patients' quality of life. Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass. METHODS After IRB approval, 277 patients undergoing cardia...

We recently developed ultra-sensitive ethanol receptors (USERs) as a novel tool for investigation of single receptor subunit populations sensitized to extremely low ethanol concentrations that do not affect other receptors in the nervous system. To this end, we found that mutations within the extracellular Loop 2 region of glycine receptors (GlyRs) and γ-aminobutyric acid type A receptors (GABA...

Objective- To compare the time of onset, duration of action and the extent of analgesia produced by a lidocaine/xylazine combination with that produced by lidocaine and xylazine alone after injection into the caudal extradural space of the Iranian river buffalo. Design- Observer-blind prospective descriptive trial, Latin square design.   Animals-  Eleven adult (aged over 2 years) female non-...

BACKGROUND Enhanced recovery after surgery (ERAS) programs typically utilizes multi-modal analgesia to reduce perioperative opioid consumption. Systemic lidocaine is used in several of these ERAS algorithms and has been shown to reduce opioid use after colorectal surgery. However it is unclear how much the other components of an ERAS protocol contribute to the final outcome. Using a noninferior...

The serum and urine levels of lidocaine and two active dealkylated metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX), were determined by HPLC in 33 cardiac patients receiving lidocaine for more than 1 day. Clinical assessment of nervous system toxicity was carried out at the time of blood drawing. The ratios in serum of MEGX to lidocaine and of GX to lidocaine were 0.36 +/- ...

aim and background:   controlling pain in the post-operative period is still one of the challenging issues for anaesthesiologists as it tremendously helps patients to return to their daily life as soon as possible. in this survey we have tried to compare the efficacy of %0.5 bupivacaine and %2 lidocaine with normal saline for controlling pain after pcnl. methods and materials:   in a double bli...

Background:Surgical site infection (SSI) is the third most common nosocomial infection, associ­ated with higher morbidity and mortality rates as well increased cost prolonged hospital stay for patients. Lidocaine, in addition to being a readily available accessible local anesthetic, has shown antimicrobial fungicidal activity. Objectives: Assessing outcome of using 2% lidocaine irrigation preve...