O Lúpus Eritematoso Sistêmico (LES) e a Síndrome do Anticorpo Antifosfolípide (SAAF) podem causar diversas manifestações no sistema cardiovascular, sendo endocardite de Libman-Sacks (ELS), uma rara manifestação cardíaca destas doenças. Trata-se um tipo trombótica não bacteriana, na qual ocorre formação trombos fibrinoplaquetários secundária depósitos imunoglobulinas complemento endocárdio, o qu...

Cardiac involvement is one of the main complications substantially contributing to the morbidity and mortality of patients suffering from systemic autoimmune diseases. All the anatomical heart structures can be affected, and multiple pathogenic mechanisms have been reported. Non-organ-specific autoantibodies have been implicated in immune complex formation and deposition as the initial triggers...

Libman-Sacks endocarditis (LSE), characterized by verrucous vegetations formation, is a typical cardiac manifestation of autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). It primarily leads to lesions of cardiac valves and mostly involved valves are mitral and aortic, but isolated tricuspid valve involvement is exceptional. Here we reported a 20...

Childhood-onset Systemic Lupus Erythematosus (SLE) has an incidence of 0.3-0.9/100,000 children. It is very rare to find a case childhood-onset SLE before 5 years age. We describe 4-year-old female child, from low-socioeconomic background who was diagnosed with based on typical rash, oral ulcer, positive laboratory parameters such as ANA, anti-ds DNA, anti-nucleosome, anti-histone antibodies, a...

Abnormality of a valve predisposes to bacterial endocarditis, even when mechanical beating action is absent, as in destruction of a cusp by previous rheumatic disease. Yet the formation of vegetations at sites other than valvular endocardium is rare; and, in spite of the frequency and apparent suitability of aortic ulcers, no report of bacterial endarteritis upon simple atheroma has been found ...