نتایج جستجو برای: lgals3

تعداد نتایج: 249  

Journal: :Cancer research 2012
Russell R Braeuer Maya Zigler Takafumi Kamiya Andrey S Dobroff Li Huang Woonyoung Choi David J McConkey Einav Shoshan Aaron K Mobley Renduo Song Avraham Raz Menashe Bar-Eli

Melanoma is the deadliest form of skin cancer in which patients with metastatic disease have a 5-year survival rate of less than 10%. Recently, the overexpression of a β-galactoside binding protein, galectin-3 (LGALS3), has been correlated with metastatic melanoma in patients. We have previously shown that silencing galectin-3 in metastatic melanoma cells reduces tumor growth and metastasis. Ge...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Vincent Bischoff Rubén Deogracias Françoise Poirier Yves-Alain Barde

Pilocarpine injection induces epileptic seizures in rodents, an experimental paradigm extensively used to model temporal lobe epilepsy in humans. It includes conspicuous neuronal death in the forebrain and previous work has demonstrated an involvement of the neurotrophin receptor p75(NTR) in this process. Following the identification of Galectin-1 (Gal-1) as a downstream effector of p75(NTR), w...

Journal: :Cancer research 2005
Barbara Jarzab Malgorzata Wiench Krzysztof Fujarewicz Krzysztof Simek Michal Jarzab Malgorzata Oczko-Wojciechowska Jan Wloch Agnieszka Czarniecka Ewa Chmielik Dariusz Lange Agnieszka Pawlaczek Sylwia Szpak Elzbieta Gubala Andrzej Swierniak

The study looked for an optimal set of genes differentiating between papillary thyroid cancer (PTC) and normal thyroid tissue and assessed the sources of variability in gene expression profiles. The analysis was done by oligonucleotide microarrays (GeneChip HG-U133A) in 50 tissue samples taken intraoperatively from 33 patients (23 PTC patients and 10 patients with other thyroid disease). In the...

2016
Jessica Jen-Chu Wang Christoph Rau Rozeta Avetisyan Shuxun Ren Milagros C Romay Gabriel Stolin Ke Wei Gong Yibin Wang Aldons J Lusis

We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting. We characterized the changes in cardiac structure and function in response to chronic isoproterenol infusion using echocardiography in a panel of 104 inbred mouse strains. We showed that cardiac stru...

2015
Yosuke Harazono Dhong Hyo Kho Vitaly Balan Kosei Nakajima Victor Hogan Avraham Raz

Galectin-3 (Gal-3, LGALS3) is a pleotropic versatile, 29-35 kDa chimeric gene product, and involved in diverse physiological and pathological processes, including cell growth, homeostasis, apoptosis, pre-mRNA splicing, cell-cell and cell-matrix adhesion, cellular polarity, motility, adhesion, activation, differentiation, transformation, signaling, regulation of innate/adaptive immunity, and ang...

2015
Aditi Bauskar Wendy J. Mack Jerome Mauris Pablo Argüeso Martin Heur Barbara A. Nagel Grant R. Kolar Martin E. Gleave Takahiro Nakamura Shigeru Kinoshita Janet Moradian-Oldak Noorjahan Panjwani Stephen C. Pflugfelder Mark R. Wilson M. Elizabeth Fini Shinwu Jeong Alexander V. Ljubimov

Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
Y Huang M Prasad W J Lemon H Hampel F A Wright K Kornacker V LiVolsi W Frankel R T Kloos C Eng N S Pellegata A de la Chapelle

Papillary thyroid carcinoma (PTC) is clinically heterogeneous. Apart from an association with ionizing radiation, the etiology and molecular biology of PTC is poorly understood. We used oligo-based DNA arrays to study the expression profiles of eight matched pairs of normal thyroid and PTC tissues. Additional PTC tumors and other tissues were studied by reverse transcriptase-PCR and immunohisto...

2016
Javier Mariscal Marta Alonso-Nocelo Laura Muinelo-Romay Jorge Barbazan Maria Vieito Alicia Abalo Antonio Gomez-Tato Casares de Cal Maria de los Angeles Tomas Garcia-Caballero Carmela Rodriguez Elena Brozos Francisco Baron Rafael Lopez-Lopez Miguel Abal

Knowledge on the molecular mechanisms underlying metastasis colonization in Non-Small Cell Lung Cancer (NSCLC) remains incomplete. A complete overview integrating driver mutations, primary tumour heterogeneity and overt metastasis lacks the dynamic contribution of disseminating metastatic cells due to the inaccessibility to the molecular profiling of Circulating Tumour Cells (CTCs). By combinin...

2017
Sofia Nascimento dos Santos Helen Sheldon Jonathas Xavier Pereira Christopher Paluch Esther M Bridges Márcia Curry El-Cheikh Adrian L Harris Emerson Soares Bernardes

Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by hypoxic changes in the glycosylation status of endothelial cells that enhance binding to gal-3. G...

2014
Helaine M Alessio Hayden Ansinelli Caitlyn Threadgill Ann E Hagerman

Lifelong physical inactivity is associated with morbidity in adulthood, possibly influenced by changes in gene and protein expressions occurring earlier in life. mRNA (Affymetrix gene array) and proteomic (2D-DIGE MALDI-TOF/MS) analyses were determined in cardiac tissue of young (3 months) and old (16 months) Sprague-Dawley rats housed with no access to physical activity (SED) versus an exercis...

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