The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...

This article addresses the varied possibilities for following a two-level fractional factorial with another fractional factorial half the size of the original experiment. While follow-up fractions of the same size as an original experiment are common practice, in many situations a smaller follow-up experiment will suffice. Peter John coined the term “semifolding” to describe using half of a fol...

Measurement bias refers to systematic differences across subpopulations in the relation between observed test scores and the latent variant underlying the test scores. Comparisons of subpopulations with the same score on the latent variable can be expected to have the same observed test score. Measurement invariance is therefore one of the key issues in psychological testing. It has been establ...

incorporation of functional foods and nutraceuticals such as carotenoids which suffer from poor water solubility and low bioavailability into nano-sized delivery systems can improve their solubility, stability and oral bioavailability. the aim of this study was to prepare β-carotene nanodispersion and investigate the effects of preparation parameters by means of response surface methodology usi...

In this paper, the issue of balance pattern of the interaction columns of a symmetrical design is considered according to orthogonal components system. The minimum interaction unbalance criterion is proposed for ranking and comparing s-level factorial designs, where s is any a prime or a prime power. It is further showed that the interaction unbalance pattern is just the generalized wordlength ...