A major goal in cancer medicine is to find selective drugs with reduced side effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will be a promising drug target with anti-cancer selectivity. Wet-lab screening approach is still so c...

BACKGROUND Lower serotonergic activity correlates with high-lethality suicide attempts in major depression. Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt. METHODS Depressed patients with a history of a high-lethality ...

The objective: to study changes and prognostic significance of the blood NT-proBNP in patients with pulmonary sepsis. Subjects Methods. included 34 aged 54.5 ± 2.9 years sepsis or septic shock. Lethality intensive care unit (ICU) was 47.1%. NT-proBNP, procalcitonin (PCT) levels, lactate hemodynamic parameters were registered on 1st day (stage 1) 4th-5th ICU stay 2). Hemodynamics assessed throug...

The Saccharomyces genome-deletion project created >5900 'molecularly barcoded' yeast knockout mutants (YKO mutants). The YKO mutant collections have facilitated large-scale analyses of a multitude of mutant phenotypes. For example, both synthetic genetic array (SGA) and synthetic-lethality analysis by microarray (SLAM) methods have been used for synthetic-lethality screens. Global analysis of s...

Age-related cognitive changes may contribute to impairments in making complex social decisions. Interpersonal conflict is a key factor behind suicidal behavior in old age, with suicidal motivations ranging from escape to revenge. Such conflicts may prove catastrophic for people prone to suicide, in part because of their tendency to make disadvantageous decisions. Yet, little is known about soci...

Acute poisoning is a sudden and potentially life threatening damage of human health, characterised by quick dynamics and high lethality. The death rate and the lethality from acute poisonings vary between countries and depend on the complex action of various medico-social factors. We have studied the hospital lethality from acute exogenous intoxications in the Toxicology Clinic of Emergency Med...

BACKGROUND People who attempt suicide often display cognitive impairments, particularly poor cognitive control. Could poor cognitive control contribute to high suicide rates in old age? A component of cognitive control, cognitive inhibition-active suppression of task-irrelevant processing-is very sensitive to aging and has been linked to attempted suicide. We investigated cognitive inhibition i...

The Suicide Upsetness Assessment (SUA) was used to measure the phenomenological experience of emotional upset during active states of suicidal ideation. Forty-nine inpatients with a history of suicide-related behaviors at a Midwestern inpatient psychiatric hospital completed a battery of assessments during their inpatient hospital stay. After reviewing theories regarding suicidality by the rese...

OBJECTIVE To determine the effect of temperature on lethality of venom from Chironex fleckeri (the potentially fatal box jellyfish). DESIGN Venom extracted from nematocysts of mature Chironex fleckeri specimens was exposed to temperatures between 4 degrees C and 58 degrees C for periods of two, five or 20 minutes, and then injected into freshwater crayfish (Cherax quadricarinatus) to assess l...