INTRODUCTION The aim of the study was to compare haemoglobin and red cell counts between patients known to be infected with a range of leptospiral serovars. METHODS The study retrospectively compared the haemoglobin and red cell count results from the first blood samples taken from 207 patients at presentation to a Queensland Health hospital. RESULTS Significant differences were observed in...

L eptospirosis is a worldwide zoonotic disease caused by infection with the spirochete bacterium Leptospira inteTragons.L. interrogans is further divided on the basis of antigenic relatedness into serogroupsand serovars. Approximately 200 different serovars of L. interrogans have been identified, and within a geographic region, certain serovars are prevalent and becomeadapted to a particular ma...

Changes in lipid fractions were evaluated in young guinea pigs when infected with 1 ml of 7 day old live cultures of leptospira interrogans serovars australis, canicola and icterohaemorrhagiae. Statistically significant elevation in triglycerides, very low density lipoprotein and phospholipid and a significant reduction in high density lipoprotein (HDL) in all the groups was observed. Cholester...

A man was admitted to the Johannesburg Hospital with a history of fever, diarrhoea, and dry cough for four days. He began to produce bloodstained sputum and was found to have severe arterial hypoxaemia. Radiography showed widespread opacification over both lung fields, and the clinical and haemodynamic features were consistent with the adult respiratory distress syndrome. Serology for Leptospir...

Aim: To study the seroprevalence of leptospirosis in dogs in Kerala and to identify the most prevalent serovar. Materials and Methods: A total of 205 sera collected from dogs were screened for the presence of antibodies against leptospirosis by Microscopic Agglutination Test (MAT). Results: A seroprevalence rate of 71.12 per cent was observed. Leptospira interrogans serovar Autumnalis was found...

BACKGROUND In the present study the efficacy and cross protection of a novel ready-to-use combination vaccine, Porcilis® Ery + Parvo + Lepto, against swine leptospirosis, was investigated. The octavalent vaccine contains inactivated antigens of Erysipelothrix rhusiopathiae, Parvovirus and 6 Leptospira interrogans sensu lato strains of serogroups Canicola, Icterohaemorrhagiae, Grippotyphosa, Aus...

Nobivac® Lepto (MSD Animal Health) is a non-adjuvanted canine leptospirosis vaccine containing inactivated whole cells of Leptospira interrogans serogroup Canicola serovar Portlandvere and L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni. The current standard in vivo potency test is a hamster challenge test associated with major drawbacks such as animal suffering and poor reprod...