BACKGROUND Heterogeneity in B-type natriuretic peptide (BNP) levels, especially among individuals with acute heart failure with normal left ventricular ejection fraction (HFNEF), can cause confusion in interpreting results. We investigated the characteristics of cases of acute HFNEF with only modestly elevated BNP. METHODS One hundred forty-two patients with acute or acute exacerbation of chr...

BACKGROUND The leptin receptor-deficient db/db mouse is a well-established type II diabetes animal model used to investigate diabetic cardiomyopathy. Previous reports have documented diabetic cardiomyopathy is accompanied by cardiac structural and functional abnormalities. To better elucidate early or subtle changes in cardiac performance in db/db mice, we used speckle tracking echocardiography...

Measurements of the thickness of the septum were made in 26 cardiac specimens and in 13 patients. There were 10 normal specimens, five with aortic stenosis, two with asymmetric septal hypertrophy, four with hypertensive cardiovascular disease, and five with idiopathic cardiomyopathy. Patient measurements were obtained by visualizing the septum during simultaneous left and right ventriculography...

This report describes a subgroup of 17 patients with hypertrophic cardiomyopathy and an unusual and distinctive pattern of left ventricular hypertrophy characterized on echocardiography by marked thickening of the posterior left ventricular free wall and virtually normal or only modestly increased ventricular septal thickness. This distribution of hypertrophy often created a distinctive pattern...

Cardiomyopathy is an important and frequently life limiting manifestation of Friedreich's ataxia (FA), the most prevalent form of autosomal recessive ataxia. Left ventricular mass is used as primary outcome measure in recent intervention studies but systematic analyses of FA cardiomyopathy are sparse. To assess cardiac hypertrophy by cardiac magnetic resonance imaging (MRI) in vivo, we assessed...

conclusions our results demonstrated the ability of pw-tdi and s/sr modalities in detection of the early subclinical abnormalities in asymptomatic patients with significant chronic ar. results ar group had significantly increased lv end systolic and end diastolic volumes, interventricular septum and posterior wall thickness compared to controls. in ar, sm and em of septal wall, sm of lateral wa...

We measured left ventricular chamber dimension and wall thickness using M-mode echocardiography in 61 adolescents with systolic or diastolic blood pressures above the 90th percentile for age and sex and in 49 norraoteosive adolescents. Left ventricular posterior wall and ventricular septal thickness indexed to body surface area were significantly greater (p < 0.001) in the hypertensive group th...

N Engl M Med 2004;350:1320-7. Copyright © 2004 Massachusetts Medical Society. A 28-year-old man presents with a two-year history of increasing dyspnea on strenuous exertion and is found to have hypertrophic cardiomyopathy, with a septal thickness of 23 mm and a left ventricular outflow gradient of 80 mm Hg. There is no family history of hypertrophic cardiomyopathy or sudden death. Forty-eight-h...

INTRODUCTION Right ventricular septal pacing is thought to be better than right ventricular apical pacing for shortening the QRS duration and for preserving left ventricular function. However, right ventricular septal pacing may not be effective in all cases. In this case report, we present a rare case in which right ventricular septal pacing induced thoroughly separated right and left ventricu...

In this study, we aimed to assess the effects of iron deficiency (ID) on cardiac functions with M-mode, pulse Doppler, and tissue Doppler and to compare the findings with healthy individuals. Twenty one children with only ID (prelatent ID + latent ID + manifest ID/anemia) and completely healthy 23 children were included in the study. Of all patients, complete blood counts were studied, and seru...