Resumo Introdução Considerando-se a magnitude da hipertensão arterial sistêmica e suas complicações, assim como importância atividade física regular na sua prevenção e/ou tratamento, é necessário identificar os fatores associados à prática de insuficiente. Objetivo Analisar insuficiente em hipertensos atendidos atenção primária saúde. Método Estudo transversal realizado com amostra aleatória 30...

OBJECTIVE Adult growth hormone deficiency (AGHD) is associated with an adverse lipid profile. The majority of previous studies of GH replacement have used supraphysiological doses and reported favourable changes in the lipid profile. Whether this beneficial effect is the result of pharmacological GH therapy, or occurs in response to low-dose GH replacement aimed at normalization of the serum IG...

OBJECTIVES Evaluate cardiovascular risk factors in Portuguese obese children and adolescents and the long-term effects of lifestyle modifications on such risk factors. DESIGN Transversal cohort study and longitudinal study. SETTING University Hospital S. João and Children's Hospital Maria Pia, Porto. PATIENTS/PARTICIPANTS 148 obese children and adolescents [81 females (54.7%); mean age of...

Polymorphisms in the apolipoprotein-E (apoE) gene may modulate lipoprotein metabolism at different steps and influence total and low density lipoprotein (LDL) cholesterol (LDLc) levels, as well as other lipid features. Population studies have documented significant differences in the frequency of apoE alleles which are related to the prevalence of various cardio-vascular and neuro-psychiatric d...

BACKGROUND Many studies showed a moderate cholesterol-lowering effect of plant sterols (PS), but increased circulating PS might be atherogenic. We evaluated the associations between natural dietary intake of PS and carotid intima-media thickness (IMT) and serum lipids. METHODOLOGY/PRINCIPAL FINDINGS This community-based cross-sectional study included 1160 men and 2780 women aged 31-75 years. ...

Serum lipids and lipoproteins were measured in 67 high-risk children, aged between 2 and 17 years, who were the offspring of 33 fathers with hypercholesterolaemia. 18 of the 33 fathers had had a myocardial infarction (MI) before 44 years of age. In 15 of the fathers there was no history of accelerated coronary heart disease (CHD). No difference in the concentrations of the serum lipids and lipo...

BACKGROUND The exact pathogenic mechanism of knee osteoarthritis (OA) is still unknown. With the exception of clinical treatment to alleviate symptoms, or total knee replacement, there is currently no effective treatment method. Consequently, an in-depth etiological and epidemiological study of knee OA can provide clues for diagnosis, treatment and scientific research, and will ultimately have ...

We investigated the response of lipoprotein(a) [Lp(a)] levels to dietary fat and cholesterol in 633 baboons fed a series of 3 diets: a basal diet low in cholesterol and fat, a high-fat diet, and a diet high in fat and cholesterol. Measurement of serum concentrations in samples taken while the baboons were sequentially fed the 3 diets allowed us to analyze 3 Lp(a) variables: Lp(a)(Basal), Lp(a)(...

BACKGROUND HIV infection has commonly been found to affect lipid profile and antioxidant defense. OBJECTIVES To determine the effects of Human Immunodeficiency Virus (HIV) infection and viral subtype on patient's cholesterol and oxidative stress markers, and determine whether in the absence of Highly Active Antiretroviral Therapy (HAART), these biochemical parameters could be useful in patien...