ABSTRACT: 10 Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted 11 simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound12 sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule 13 drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. ...

Let e and n be positive integers and S = {x1, . . . , xn} be a set of n distinct positive integers. The n × n matrix having eth power [xi, xj ] of the least common multiple of xi and xj as its (i, j)-entry is called the eth power least common multiple (LCM) matrix on S, denoted by ([S]). The set S is said to be gcd closed (respectively, lcm closed) if (xi, xj) ∈ S (respectively, [xi, xj ] ∈ S) ...

introduction there is very limited literature describing the association of lateral condyle mass (lcm) fracture of the distal humerus associated concurrently with olecranon fracture. herein, a case is reported of a displaced lcm fracture with displaced olecranon fracture, due to complex trauma while getting out of a vehicle, which was managed by open reduction and internal fixation. conclusions...

s t lcm lcm*2 lcm*4 gcd gcd/2 gcd/4 s t lcm lcm*2 lcm*4 gcd gcd/2 gcd/4 Table 1: Execution times (ms) for cyclic(s) to cyclic(t) redistribution on 32 processors. other block sizes t. Fig. 3 shows the total times in milliseconds for a cyclic(192) to cyclic(8) redistribution on 32 processors for increasing data sizes. This redistribution corresponds to the cyclic(Y t) to cyclic(t) case with Y = 2...

Laser capture microdissection (LCM) has become an important tool in biological research, permitting isolation of specific cell populations from frozen tissue samples containing a mixture of cell types. Cells obtained by LCM can be directly analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). We report here methodology for the preparation and analysis of LCM capt...

Magnified endoscopic observation of the gastrointestinal tract has become possible. However, such observation at the cellular level remains difficult. Laser-scanning confocal microscopy (LCM) is a novel, noninvasive optical imaging method that provides instant microscopic images of untreated tissue under endoscopy. We compare prototype catheter-based reflectance-type LCM images in vivo and hist...

BACKGROUND HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa. METHODS In this open, non-inferiority trial in three centr...

This study aims to optimize the void function by engineering material handling so that in post-mining stage it is expected Void Northern area of 40 Ha with drainage RL 20 and Southern 140 11 be used as a source irrigation for rice fields become location planned infrastructure development Solar Power Plants. Descriptive quantitative data analysis assisted using Geovia Minex, X Pac, Autocad Land ...

Let S = {x1,x2, . . . ,xn} be a set of positive integers, and let f be an arithmetical function. The matrices (S) f = [ f (gcd(xi,xj))] and [S] f = [ f (lcm[xi,xj])] are referred to as the greatest common divisor (GCD) and the least common multiple (LCM) matrices on S with respect to f , respectively. In this paper, we assume that the elements of the matrices (S) f and [S] f are integers and st...