Development of techniques for the continuous measurement of regional blood flow and vascular resistance in intact small animals has been impeded primarily by the bulkiness of flow probes. The availability of an ultrasonic pulsed Doppler flowmeter system enabled us to construct miniaturized probes using 1-mm-diameter piezoelectric crystals that emit a 20-mHz signal and receive the reflected soun...

Aim: To evaluate the interobserver variability and retest reproducibility of confocal scanning laser Doppler flowmeter in measuring capillary perfusion of the peripapillary retina. Methods: Blood flow measurements were performed in one eye of 10 normal subjects by two investigators on two different days (visits). Five separate measurements of the peripapillary blood flow parameters were recorde...

  It has been shown that acute inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow. To investigate the role of vascular β- adrenoceptors in this event, 12 NZW rabbits were maintained anaesthetized by 1 % halothane in N2O/O2, and acute knee joint inflammation was induced by intra-articular injection of 1 ml of 2% carageenan solution 24 hours be...

This year we celebrate 60 years since Shigeo Satomura published the first measurements of the Doppler shift of ultrasonic signals from a beating heart. He demonstrated that Doppler signals can be retrieved from heart movements when insonated with 3 MHz ultrasonic waves. Later, togheter with Ziro Kaneko, he constructed the first Doppler flowmeter to measure the blood flow velocities in periphera...

A noninvasive method to accurately quantitate the severity of mitral insufficiency would be of major clinical value. In theory, in the absence of confounding variables, regurgitant mitral flow should represent the difference between forward mitral blood flow and aortic blood flow. Since Doppler-two-dimensional echocardiographic (D2DE) methods for measuring transvalvular mitral and aortic flow h...

Abstract Daikenchuto is a traditional Kampo medicine used to treat cold sensations and dysmotility in the abdomen. This study investigated roles of transient receptor potential ankyrin 1- reporter vanilloid 1-expressing sensory nerves daikenchuto-induced gastric mucosal blood flow by pharmacological immunohistochemical analyses using male Sprague-Dawley rats. Gastric was measured ex vivo stomac...

ranolazine is a new antianginal drug that is postulated to act through blocking of cardiac late sodium channels and improvement in cardiac blood flow. the present study has been carried out to investigate its possible effect on microcirculation of normal and diabetic rats’ cardiac muscle. methods: normal and diabetic rats were anesthetized. the chest was opened and a surface laser doppler flowm...