Background: Probiotic formulations can be single- or multi-strain. Commercially, multi-strain preparations have been suggested to have improved functionality over single-strain cultures. Probiotics are often tested as single-strain preparations but may subsequently be commercially formulated as multi-strain products. Objective: The aim of this study was to determine what happens at the site of ...

Background: The health benefits of probiotic bacteria are not unknown to anyone. On the other hand, indigenous dairy sources are a potential source of native probiotics. This study aimed to describe the inhibitory activity of Cell-Free Supernatant (CFS), planktonic cells, and biofilm form of Lactobacillus strains isolated from native dairy sources on food pathogens. Methods: Antibacterial acti...

Probiotics and antibiotics are widely used in poultry and may alter drug bioavailability by affecting the expression of intestinal ATP-binding cassette (ABC) efflux transporters. Therefore the aim of the present investigation was to evaluate the effect of Lactobacilli probiotics, administered alone or in combination with doxycycline, on the expression of ABCB1 (gene, encoding P-glycoprotein), A...

Helicobacter pylori (H. pylori), with more than 50% global population infection, is an etiology of chronic gastritis and peptic ulcer and a risk factor for gastric malignancies. Due to the increase of H. pylori-resistant strains and treatment-related adverse effects, the success rate of eradication therapies has declined to 70%, far below the initial rate of 90%. To improve the eradication rate...

Researches concerning probiotics were initiated by a Russian scientist named Elie Metchnikoff. He emphasized the importance of Lactobacillus species and fermented milk products present in the gastrointestinal tract for a healthy and long life. The term "probiotics" was first introduced in 1953 by Werner Kollath, and he defined probiotics as microbially derived factors that stimulate the growth ...

OBJECTIVE To assess impact of probiotics and breastfeeding on gut microecology. STUDY DESIGN Mothers were randomized to receive placebo or Lactobacillus rhamnosus GG before delivery, with treatment of the infants after delivery. We assessed gut microbiota, humoral immune responses, and measured soluble cluster of differentiation 14 (sCD14) in colostrum in 96 infants. RESULTS Fecal Bifidobac...

BACKGROUND The efficacy of probiotics for the prevention of Clostridium difficile infection (CDI) is highly controversial, particularly with regard to the prevention of recurrent CDI. We hypothesize that primary prevention of CDI among patients receiving antibiotics might be a more achievable goal for probiotics than prevention in patients with previous CDI where the host flora is markedly alte...