There are many types of investigation connected with the tumor problem for which a large laboratory animal such as the rabbit would be more useful than a small one such as the mouse. For problems connected with experimental carcinogenesis the limiting factor is, naturally, the availability of a suitable carcinogen. Neither tar nor 3,4-benzpyrene can be considered as suitable for the rabbit: The...

BACKGROUND AND PURPOSE Action potential (AP) recordings in ex vivo heart preparations constitute an important component of the preclinical cardiac safety assessment according to the ICH S7B guideline. Most AP measurement models are sensitive, predictive and informative but suffer from a low throughput. Here, effects of selected anti-arrhythmics (flecainide, quinidine, atenolol, sotalol, dofetil...

Olfactory-specific cytochrome P450NMb was previously purified to electrophoretic homogeneity from microsomes of rabbit nasal mucosa in this laboratory. In the present study, a cDNA library made from poly(A)+ RNA from rabbit nasal mucosa was screened with antibodies to this P450, and eight immunopositive clones were isolated and characterized. The sequence determined from two overlapping clones ...

To date, the laboratory mouse is the only mammal in which freeze-dried spermatozoa have been shown to support full-term development after microinjection into oocytes. Because spermatozoa in mice, unlike in most other mammals, do not contribute centrosomes to zygotes, it is still unknown whether freeze-dried spermatozoa in other mammals are fertile. Rabbit sperm was selected as a model because o...

The characteristic distribution of uterine cancer in man with a high incidence in the cervix and a low frequency in the fundus does not obtain in the rabbit. Carcinoma of the uterine fundus is by far the most common of all neoplasms in the rabbit (1) whereas cervical cancer has not been observed in our laboratory nor has its occurrence been reported in the literature. The absence of a squamocol...

As a monogastric herbivore, the rabbit presents a unique feeding behaviour compared to other domestic animals, since he belongs to the Lagomorpha order (Leporidae family: rabbits and hares, Grassé and Dekeuser, 1955), and consequently possess a main specificity that is the caecotrophy. For recall (see details in chapter 1), the caecotrophy is a complete behaviour involving an excretion and an i...

Transmission of the bacterium occurs primarily through bites from arthropods, including the dog tick (Dermacentor variabilis), the wood tick (D. andersoni), the lone star tick (Amblyomma americanum), and the deer fl y (Chrysops spp.). In addition, contact with infected animals, most commonly rabbits, wild rodents, and cats, is another common route of transmission to humans (1,6). Tularemia occu...

The rabbit has great commercial importance as a source of meat and fur, as well as its uses as a laboratory animal for the production of antibodies, used to detect the presence or absence of disease and for research in infectious diseases and immunology. One of the most critical problems in immunology is to understand how the immune system detects the presence of infectious agents and disposes ...

In this study, cottontail rabbit papillomavirus infection of domestic rabbits was used as an animal model to develop papillomavirus early gene-based vaccines. Groups of rabbits were intracutaneously vaccinated with single papillomavirus early genes E1, E2, E6, and E7 or with a combination of these four genes. Only a fraction of rabbits were protected from subsequent viral challenge when vaccina...

A cell-free protein-synthesizing system derived from rabbit reticulocytes is described which is dependent on the addition of transfer RNA for the translation of endogenous hemoglobin messenger RNA. Product analysis indicates that the system is active in the initiation of new chains. When hemoglobin is synthesized in the presence of a limiting amount of tRNA, there is a 50% decrease in (Y chain ...