background: chlorotoxin is a 36-amino acid peptide found in the venom of the leiurus quinquestriatus which blocks small-conductance chloride channels. chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. thus chlorotoxin derivative was labeled with 131i for further investigation. materials and methods:...

This chapter summarizes details pertaining to the extracellular recording and juxtacellular labeling method and its application to the characterization of basal forebrain neurons. Juxtacellular labeling is compared to other single-cell labeling techniques. Compatibility of the method with fluorescent retrograde/anterograde neural tracing, immunohistochemical, and electron microscopy techniques ...

Cellular magnetic resonance imaging (MRI) has been well-established for tracking neural progenitor cells (NPC). Superparamagnetic iron oxide nanoparticles (SPIONs) approved for clinical application are the most common agents used for labeling. Conventionally, transfection agents (TAs) were added with SPIONs to facilitate cell labeling because SPIONs in the native unmodified form were deemed ine...

The sortase-mediated labeling method, whose applications have been limited to C-terminal labeling of cell surface proteins, has been expanded for site-specific N-terminal labeling of cell surface proteins.

Automated labeling of anatomical structures in medical images is very important in many neuroscience studies. Recently, patch-based labeling has been widely investigated to alleviate the possible mis-alignment when registering atlases to the target image. However, the weights used for label fusion from the registered atlases are generally computed independently and thus lack the capability of p...

INTRODUCTION: Arterial Spin Labeling (ASL) is an established technique for non-invasive measurement of cerebral perfusion. In conventional ASL, blood spins of all large feeding arteries are inverted in a slab perpendicular to them to acquire an image of the entire brain perfusion. To visualize the vascular territories of single arteries rather than the whole vascular tree the method of regional...