The worldwide dissemination of extended-spectrum-β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae is a major concern in both hospital and community settings. Rapid identification of these resistant pathogens and the genetic determinants they possess is needed to assist in clinical practice and epidemiological studies. A collection of Escherichia coli, Klebsiella pneumoniae, Kl...

Background. We aimed to study the molecular characteristics and clonal structure of carbapenemase-producing Enterobacteriaceae(CPE) in post-acute care facilities (PACF’s) in Israel and to analyze the temporal changes that have occurred between 2008 and 2013. Methods. The prevalence of CPE carriage in PACF’s in Israel was determined in two point prevalence national surveys done in 2008 and 2013....

the Centers for Disease Control and Prevention/ National Healthcare Safety Network, are primarily designed for surveillance purposes, and only patients with KPC-2-Kp bacteriuria who do not meet these criteria are thought to have urinary tract infection and receive treatment. The results presented here show that the outcomes of CRE bacteriuria/bacteremia are influenced by both the choice of anti...

We report four epidemiologically unrelated cases of KPC-carrying Klebsiella pneumoniae identified in Switzerland between May 2009 and November 2010. Three cases were transferred from Italy (two KPC-3, one KPC-2) and one from Greece (KPC-2). Resistance to colistin and doxycycline emerged in one KPC-3-carrying K. pneumoniae strain during therapy. These results demonstrate ongoing dissemination of...

A carbapenem-resistant Klebsiella pneumoniae strain 628 was isolated from a human case of intracranial infection in a Chinese teaching hospital. Strain 628 produces KPC-2 and CTX-M-55 encoded by two different conjugative plasmids, i.e., the IncFIIK plasmid p628-KPC and the IncI1 plasmid p628-CTXM respectively. bla KPC-2 is captured by a Tn1722-based unit transposon with a linear structure. ΔTn3...

Sir, The production of carbapenem-hydrolysing b-lactamases is increasingly reported in Enterobacteriaceae. Among the different types of carbapenemases, the emergence of the Ambler class A KPC-type b-lactamases is of great concern, since those enzymes hydrolyse all b-lactams with the exception of cephamycins. Enterobacterial isolates producing KPC-type b-lactamases were reported in many areas in...

BACKGROUND Previous studies may have overestimated morbidity and mortality due to Klebsiella pneumoniae producing carbapenemase (KPC) Klebsiella pneumoniae infections because of difficulties in modeling patient comorbidities. This pilot study sought to evaluate KPC virulence by combining clinical and Galleria mellonella models in patients with K. pneumoniae blood stream infections (BSIs). MET...