Aim Extending and generalizing the computational concept of analog series-based (ASB) scaffolds. Materials & methods Methodological modifications were introduced to further increase the coverage of analog series (ASs) and compounds by ASB scaffolds. From bioactive compounds, ASs were systematically extracted and second-generation ASB scaffolds isolated. Results More than 20,000 second-gener...

BACKGROUND The inhibitory effect of andrographolide sodium bisulphite (ASB) on jack bean urease (JBU) and Helicobacter pylori urease (HPU) was performed to elucidate the inhibitory potency, kinetics and mechanism of inhibition in 20 mM phosphate buffer, pH 7.0, 2 mM EDTA, 25 °C. METHODS The ammonia formations, indicator of urease activity, were examined using modified spectrophotometric Berth...

The primary purpose of the present study was to examine support for the inclusion of relational aggression (RAgg) alongside physical aggression (Agg) and rule-breaking behaviors (RB) as a subfactor of antisocial behavior (ASB). Caregiver reports were collected for 1,087 youth (48.9% male) ages 6-18. Results indicated that all three subfactors of ASB demonstrated substantial loadings on a genera...

BACKGROUND asymptomatic bacteriuria (ASB) is common among the institutionalised elderly (IE). The cytokine levels and factors associated with ASB are unknown. OBJECTIVE to analyse cytokines and factors associated with ASB among the IE living in long-term care facilities (LTCFs) in Taiwan. METHODS this case-control study included residents ≥65 years in two LTCFs. The demographics, functional...

BACKGROUND AND AIMS The nephrotoxic mechanisms of andrographolide sodium bisulfate (ASB) remain largely unknown. This study attempted to explore the mechanism of ASB-induced nephrotoxicity using human proximal tubular endothelial cells (HK-2). METHODS For this study HK-2 cells were treated with rising concentrations of ASB. Their survival rate was detected using MTT assay and ultrastructure w...

Arylsulphatases B (ASB) and A (ASA) are subject to a unique post-translational modification that is required for their function. The modification reaction, conversion of an active-site cysteine into a formylglycine, becomes saturated when these enzymes are overexpressed. We have removed the possibility of in vivo modification by expressing mutants of ASB and ASA in which the active-site cystein...

BACKGROUND Detecting and treating asymptomatic bacteriuria (ASB) prevents urinary tract infection and its consequences. The cost-effectiveness of routine screening for ASB in pregnancy is controversial. In populations with high prevalence, however, it is worthwhile and justifiable. AIM To determine the profile, prevalence, microbiological isolates, and risk factors of ASB among booking antena...

Im Fachbereich Informatik der Hochschule Trier wird seit mehreren Jahren ein System zur automatischen Software-Bewertung (ASB) eingesetzt und weiterentwickelt. Das ASB-System ist eine Web-Anwendung, die es Studierenden ermöglicht, Lösungen zu Programmieraufgaben innerhalb eines festgelegten Zeitraums einzureichen. Die Lösungen werden durch zuvor installierte Programme automatisch bewertet. In d...

Dynamic testing of statically predeformed specimens of magnesium (AM50) shows that the failure strain increases with the level of prestrain. Interrupted and other dynamic tests show that the temperature rise prior to localization has only a minor influence on adiabatic shear band (ASB) formation. For all the tests, the dynamic deformation energy until ASB formation is found to be relatively con...