We continued a prospective longitudinal follow-up study of 53 remaining patients who underwent open total meniscectomy as adolescents and who at that time had no other intra-articular pathology of the knee. Their clinical, radiological and patient-reported outcomes are described at a mean follow-up of 40 years (33 to 50). The cohort of patients who had undergone radiological evaluatio...

background: knee osteoarthritis is a common degenerative joint disorder and a major cause of pain and disability. recent studies have suggested that bisphosphonates such as alendronate may have a role in the treatment of osteoarthritis. the purpose of the present study was to investigate the potential effect of alendronate on the symptoms of knee osteoarthritis.  methods: thirty nine patients w...

background osteoarthritis (oa) is a multifactorial, disabling and degenerative disease that worsens with age and affects patient’s health-related quality of life (hrqol). objectives the current study aimed to assess if age and comorbidities have an influence on knee oa and knee replacement outcome before and after the surgery. methods a quasi-experimental intervention study was conducted on a s...

Data on return to work and sport following open wedge high tibial osteotomy (HTO) have been underreported. Furthermore, there is no clear consensus in literature about the postoperative alignment goals HTO. A retrospective case series was performed evaluate The University of California, Los Angeles scale, German classification system according Reichsausschuß für Arbeitszeitermittlung, Tegner sc...

BACKGROUND AND PURPOSE There is no consensus on the impact of radiographic severity of hip and knee osteoarthritis (OA) on the clinical outcome of total hip arthroplasty (THA) and total knee arthroplasty (TKA). We assessed whether preoperative radiographic severity of OA is related to improvements in functioning, pain, and health-related quality of life (HRQoL) 1 year after THA or TKA. PATIEN...

Purpose  The purpose of this study was to determine the safety efficacy and outcomes of platelet-rich plasma (PRP) intra-articular injections for early stages of knee osteoarthritis (OA). Methods  Twenty-five patients affected by grade I and II knee primary OA according to the Kellgren-Lawrence scale received a single intra-articular PRP injection. Patients were prospectively evaluated for 6 mo...

This case report describes the early results of a 36-year-old man who underwent repair of a symptomatic full-thickness patellar cartilage defect with transplanted particulated juvenile articular cartilage. At 2 years postoperatively, the patient has experienced substantial clinical improvement in both pain and function when evaluated with both International Knee Documentation Committee subjecti...

BackgroundAnterior cruciate ligament (ACL) injury of the knee is common in young active adults and often has severe sometimes lifelong consequences. The clinical management this remains debated. A prior trial early versus delayed optional ACL repair showed no differences outcomes at 2 years.MethodsWe present 11-year follow-up a randomized involving 121 (mean age 26yo, 74% male) with an acute sp...

INTRODUCTION Second-generation autologous chondrocyte implantation with scaffolds stabilizing the grafts is a clinically effective procedure for cartilage repair. In this ongoing prospective observational case report study, we evaluated the effectiveness of BioSeed-C, a cell-based cartilage graft based on autologous chondrocytes embedded in fibrin and a stable resorbable polymer scaffold, for t...