نتایج جستجو برای: kisspeptins
تعداد نتایج: 148 فیلتر نتایج به سال:
Background: Hypothalamus-derived kisspeptins are critical regulators of reproduction in nearly all mammalian species including the humans. These small peptides mediate their actions through the GnRH loop system. How kisspeptins regulate gonadal maturation in sexually immature male mammals remains elusive. To address this, kisspeptin was administered as subchronic (12 days) twice daily i. p. dos...
Orphan G-protein-coupled receptors that have recently been paired with their cognate ligand are an often untapped resource for novel drug development. The KISS1 receptor (previously designated GPR54) has been paired with biologically active cleavage peptides of the KiSS-1 gene product, the kisspeptins (KP). The focus of this review is the emerging pharmacology and physiology of the KP. Genetic ...
The most common malignancy among Indian women is breast cancer. Patient’s ages ranging between 35 40 yrs old at diagnosis are usually considered as the endangered population [1].Breast cancer in women below 40 years is not a usual condition. However, a sudden increase in the incidence of breast cancers in premenopausal women has been reported from several countries. Though adjuvant combination ...
During the past decade, the kisspeptin system has been identified in various vertebrates, leading to the discovery of multiple genes encoding both peptides (Kiss) and receptors (Kissr). The investigation of recently published genomes from species of phylogenetic interest, such as a chondrichthyan, the elephant shark, an early sarcopterygian, the coelacanth, a non-teleost actinopterygian, the sp...
Kisspeptins (KPs) are major regulators of trophoblast and cancer invasion. Thus far, limited and conflicting data are available on KP-mediated modulation of breast cancer (BC) metastasis; mostly based on synthetic KP-10, the most active fragment of KP. Here, we report for the first time comprehensive functional effects of term placental KPs on proliferation, adhesion, Matrigel invasion, motilit...
Kisspeptins are known as neuropeptides encoded by the KISS1 gene, which potentiates GnRH neuron excitability. Unfortunately, role of gene in reproductive traits remains unclear Indonesian native goat breeds. The current study purposed to detect genetic variation and investigate association with goats acquire marker-assisted selection (MAS) for breeding program. Further, ninety blood samples fro...
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