In this issue of Blood, Keats et al,(1) Egan et al,(2) and Walker et al(3) provide a genome-wide snapshot of the clonal landscape in multiple myeloma(MM)illustrating the complexity of the evolutionary process and the dynamics of clonal evolution over time.

Abstract In this paper, we propose a novel deep learning-based feature learning architecture for object classification. Conventionally, methods are trained with supervised But, would require large amount of training data. Currently there increasing trends to employ unsupervised learning. By doing so, dependency on the availability data could be reduced. One implementation is where network desig...

Access to the published version may require subscription. nine. The met allele inhibits the intracellular trafficking and the regulated secretion of the BDNF protein at synapses (Egan et al., 2003). Several lines of evidence suggest that BDNF might be relevant for olfactory processing. It has been found to regulate the proliferation and survival of olfactory receptor neurons (ORN) in vivo (Simp...

39 Basso MR, Nasrallah HA, Olson SC, Bornstein RA. Cognitive deficits distinguish patients with adolescentand adult-onset schizophrenia. Neuropsychiatr Neuropsychol Behav Neurol 1997; 10: 107–12. 40 Nicolson R, Brookner FB, Lenane M, Gochman P, Ingraham LJ, Egan MF, et al. Parental schizophrenia spectrum disorders in childhood-onset and adultonset schizophrenia. Am J Psychiatry 2003; 160: 490–5.

Fig 2: Schematic of test coil with interchangeable detuning circuits. Pickup loops P1 and P2 are used to quantify detuning. 4879 Enhancement Mode GaN on Silicon (eGaN® FETs) for Coil Detuning Michael Twieg, Matthew J Riffe, Michael de Rooij, and Mark A Griswold Dept. of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, United States, Dept. of Biomedica...

I am grateful to Egan and Tye for their thoughtful and challenging criticisms of The Red and the Real (henceforth RR), from which I have learned much. They raise a number of interesting issues, and I am thankful for the opportunity their criticism provides to reconsider some of the key commitments of the book and attempt to clarify my thinking about these matters. While reasons of space prevent...

Parasites Christopher Merritt,‡ Lisseth E. Silva,† Angela L. Tanner,† Kenneth Stuart,‡ and Michael P. Pollastri*,† †Department of Chemistry & Chemical Biology, Northeastern University, 417 Egan Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115, United States ‡Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109-5219, United States

D. C. Nunes, R. J. Phillips, G. Picardi, J. J. Plaut, A. Safaeinili, R. Seu, and A. Egan. Lunar and Planetary Institute, Houston, TX 77058 ([email protected]), Department of Earth and Planetary Sciences and McDonnell Center for the Space Sciences, Washington University, Saint Louis, MO 63130, Infocom Department, “La Sapienza” University of Rome, 00184 Rome, Italy, Jet Propulsion Laboratory, Pa...