· To learn about the magnitude of the burden of the disease and the systemic involvement of chronic respiratory failure; · To learn about the interactions and complexity of mechanisms leading to undernutrition with compromise of metabolic active tissues, i.e. skeletal muscles; · To learn about the integration of nutritional support in pulmonary rehabilitation including exercise training for pat...

Knowledge of the fate and behaviour of the respiratory muscles during ventilatory support is important for the guidance of clinical care. Full support facilitates muscle metabolic repletion, but exposes them to the risk of disuse atrophy. The effect of partial support varies according to the selected mode: assisted mechanical ventilation (AMV) and synchronized intermittent mechanical ventilatio...

Adaptive Support Ventilation (ASV) is a fully closed loop ventilation where the operator input desired PEEP, FiO2 and target minute (MV) expressed as percentage according to ideal body weight. The ventilator selects respiratory pattern (tidal volume, rate, inspiratory time) based on observed mechanics. However, there are no published guidelines settings adjusting MV in different disease states ...