The secure deletion of data is becoming increasingly important to individuals, corporations as well as governments. Recent advances in worldwide laws and regulations now require secure deletion for sensitive data in certain industries. Data leaks in the public and private sector are commonplace today, and they often reveal data which was supposed to be deleted. Secure deletion describes any mec...

27 Deletion of NMDA receptors (NMDARs) early in development results in an increase in 28 the number of synaptic AMPA receptors (AMPARs), suggesting a role for NMDARs in 29 negatively regulating AMPAR trafficking at developing synapses. Substantial evidence 30 has shown that AMPAR subunits function differentially in AMPAR trafficking. 31 However, the role of AMPAR subunits in the enhancement of ...

Transposons comprise large fractions of eukaryotic genomes and provide genetic reservoirs for the evolution of new cellular functions. We identified TPB2, a homolog of the piggyBac transposase gene that is required for programmed DNA deletion in Tetrahymena. TPB2 was expressed exclusively during the time of DNA excision, and its encoded protein Tpb2p was localized in DNA elimination heterochrom...

The deletion-insertion channel takes as input a bit string x ∈ {0, 1}, and outputs a string where bits have been deleted and inserted independently at random. The trace reconstruction problem is to recover x from many independent outputs (called “traces”) of the deletion-insertion channel applied to x. We show that if x is chosen uniformly at random, then exp(O(log n)) traces suffice to reconst...

Deletion of N-methyl-D-aspartate receptors (NMDARs) early in development results in an increase in the number of synaptic AMPA receptors (AMPARs), suggesting a role for NMDARs in negatively regulating AMPAR trafficking at developing synapses. Substantial evidence has shown that AMPAR subunits function differentially in AMPAR trafficking. However, the role of AMPAR subunits in the enhancement of...

Background and Purpose Chronic alcohol consumption contributes to contractile dysfunction unfavourable geometric changes in myocardium, accompanied by altered autophagy disturbed mitochondrial homeostasis. The E3 ubiquitin ligase Parkin encoded PARK2 gene maintains a fundamental role regulating mitophagy homeostasis, although little is known of its the aetiology alcoholic cardiomyopathy. Here w...

Cellulolytic enzyme hydrolysis of lignocellulose biomass to release fermentable sugars is one of the key steps in biofuel refining. Gene expression of fungal cellulolytic enzymes is tightly controlled at the transcriptional level. Key transcription factors such as activator ClrB/CLR2 and XlnR/XYR1, as well as repressor CreA/CRE1 play crucial roles in this process. The putative protein methyltra...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...

This paper proposes two ways to fix the broken Square-Vinegar signature scheme. We give heuristic arguments as well as experimental evidence to support the security claims. The first variant, Square-Vinegar with Embedding, uses a simple modification that nonetheless changes the nature of the public key polynomials. The second, 2-Square-Vinegar, is a more significant overhaul of the construction...

A Monte Carlo simulation was performed to compare methods for handling missing data in growth mixture models. The considered the current study were (a) a fully Bayesian approach using Gibbs sampler, (b) full information maximum likelihood expectation–maximization algorithm, (c) multiple imputation, (d) two-stage imputation method, and (e) listwise deletion. Of five methods, it found that genera...