Plasma ketoconazole (KETO), amprenavir (APV), and ritonavir (RTV) pharmacokinetics were evaluated in 15 healthy subjects after being treated with KETO at 200 mg once daily (QD), fosamprenavir (FPV)/RTV at 700/100 mg twice daily (BID), and then KETO at 200 mg QD plus FPV/RTV at 700/100 mg BID in this open-label study. The KETO area under the concentration-time curve at steady state was increased...

Capillary Gas Chromatography (CGC) is capable of determining underivatized cyclophosphamide (CPA) using SCOT OV 275 columns. Then CPA is subjected to in situ degradation resulting in formation of a cyclization product which can be determined selectively in biological fluids. In routine bioanalysis however cyclization products of CPA metabolites might interfere, e.g. 4-keto CPA. In the present s...

α-Nitro-δ-keto nitriles and α-nitro-δ-keto ester were readily converted to diazabicyclo compounds having vicinal functionality upon treatment with diamines. The keto nitrile attracts the diamine nearby to an acidic hydrogen to cause the pseudo-intramolecular imination which proceeds efficiently without any catalyst at room temperature.

This article presents a study of the excited state relaxation dynamics N-salycylidene-o-aminophenol (SOAP) in ethanol solution. Femtosecond transient absorption (TA) spectroscopy and theoretical calculations are used combination to establish mechanism type molecular species involved accompanying phototransformations. TA spectra show that upon photoexcitation two SOAP tautomers (E-enol Z-keto) i...

Abstract The keto‐switched photocatalysis of covalent organic frameworks (COFs) for efficient H 2 evolution was reported the first time by engineering, at a molecular level, local structure and component skeletal building blocks. A series imine‐linked BT‐COFs were synthesized Schiff‐base reaction 1, 3, 5‐benzenetrialdehyde with diamines to demonstrate structural reconstruction enol keto configu...

  Introduction Renal tubular acidosis (RTA) is a non-uremic defects of urinary acidification. It is characterized by a normal anion gap hyperchloremic  metabolic acidosis; plasma potassium may be normal, low or high-depending on the type of RTA. These syndromes differ from uremic acidosis which is associated with a high anion gap, decreased glomerular filtration with enhanced proton secretion b...

TO THE EDITOR: I benefited from reading this Point:Counterpoint discussion (2, 3) and some of the papers cited therein and was shocked to learn that the construct of “lactic acidosis” has been questioned before (4). However, it is clear (from Ref. 1) that the reduction of pyruvate to lactate consumes two protons, and as Robergs et al. (4) have said, the production of lactate retards the develop...