INTRODUCTION Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive disease that causes acute or chronic hemolytic anemia and potentially leads to severe jaundice in response to oxidative agents. This deficiency is the most common human innate error of metabolism, affecting more than 400 million people worldwide. CASE PRESENTATION Here, we present the first documented case of k...

Although its cause, jaundice in the newborn, is extremely common, the disabling neurological disorder kernicterus is very rare. Kernicterus may be prevented by selecting those infants who are at risk of extreme jaundice or who may be particularly vulnerable to bilirubin neurotoxicity. Because the tools for achieving that goal are inadequate, a secondary strategy is needed. This involves a plan ...

One of the most typical clinical manifestations infant is hyperbilirubinemia. Jaundice sends more than 85% term newborns back to hospital within first week life. 60% and 80% preterm (less term) infants have If hyper bilirubin not appropriately treated, it can damage brain cells, cause seizures, progress kernicterus, even causing death. Even if newborn gets kernicterus recovers be passed, baby g...

Genetic-based susceptibility to bilirubin neurotoxicity and chronic bilirubin encephalopathy (kernicterus) is still poorly understood. Neonatal jaundice affects 60-80% of newborns, and considerable effort goes into preventing this relatively benign condition from escalating into the development of kernicterus making the incidence of this potentially devastating condition very rare in more devel...

1. Documenta – Hospital São Francisco, Ribeirão Preto, SP, Brazil. Mailing address: Dr. Rodolfo Mendes Queiroz. Documenta – Centro Avançado de Diagnóstico por Imagem. Rua Bernardino de Campos, 980, Centro. Ribeirão Preto, SP, Brazil, 14015-130. E-mail: [email protected]. structures, capable of detecting small UDs and identifying neoplasms. In T-2 weighted MRI sequences, UDs show hyperinte...

Background: Indirect hyperbilirubinemia is one of the most common causes hospitalization in neonatal period and its potential association with brain damage well established. This study was conducted to determine neurodevelopmental outcome children who had severe indirect received intensive phototherapy or without double volume exchange transfusion for management. Material & methods: descrip...