نتایج جستجو برای: kendalls tau
تعداد نتایج: 20931 فیلتر نتایج به سال:
INTRODUCTION Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer's disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau aggregates and accumulates in neurofibrillary tangles and dystrophic neurites in the brain; however, in some familial tauopathy disorders, mutations in the gene encoding tau cau...
BACKGROUND Intracellular filamentous deposits containing microtubule-associated protein tau constitute a defining characteristic of many neurodegenerative disorders. Current experimental models to study tau pathology in vitro do not usually recapitulate the tau expression pattern characteristic of adult human brain. In this study, we have investigated whether human embryonic stem cell-derived n...
The hyperphosphorylated microtubule-associated protein tau is present in several neurodegenerative diseases, although the causal relationship remains elusive. Few mouse models used to study Alzheimer-like dementia target tau phosphorylation. We created an inducible pseudophosphorylated tau (Pathological Human Tau, PH-Tau) mouse model to study the effect of conformationally modified tau in vivo....
We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner. Since murine tau might interfere with the toxic effects of human mutant tau, we set out to analyse the phenotype of our Tg30tau model in the absence of endogenou...
Fig. 4. Analysis of fully fed vs DR food effects on tau levels and phosphorylation in flies over-expressing WT human tau. (A) Tau expression and phosphorylation levels were measured by western blotting in control flies (welav/+, w;UAS-4Rtau/+), and at the indicated time points in welav/+;UAS-4Rtau/+flies treated on1.0 vs 2.0 Y medium. Primary antibodies were as follows: Anti-tau (total tau; Dak...
The tau subunit of Escherichia coli DNA polymerase III holoenzyme interacts with the alpha subunit through its C-terminal Domain V, tau(C)16. We show that the extreme C-terminal region of tau(C)16 constitutes the site of interaction with alpha. The tau(C)16 domain, but not a derivative of it with a C-terminal deletion of seven residues (tau(C)16Delta7), forms an isolable complex with alpha. Sur...
Tau, a microtubule associated protein, aggregates into intracellular paired helical filaments (PHFs) by an unknown mechanism in Alzheimer's disease (AD) and other tauopathies. A contributing factor may be a failure to metabolize free cytosolic tau within the neuron. The buildup of tau may then drive the aggregation process through mass action. Therefore, proteases that normally degrade tau are ...
Hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of Alzheimer disease (AD). Alternative splicing of tau exon 10 generates tau isoforms containing three or four microtubule binding repeats (3R-tau and 4R-tau), which are equally expressed in adult human brain. Dysregulation of exon 10 causes neurofibrillary degeneration. Here, we report that cyclic AMP-depende...
در این تحقیق اثرات باسیلوس های پروبیوتیکی بر روی انرژی مصرف شده و دفع آمونیاک و اوره در لارو ماهیان قزل آلا با بکارگیری مخلوط پنج گونه از باسیلوس های پروبیوتیکی از طریق مکمل سازی جیره به مدت 60 روز بررسی شد. لاروهای ماهی قزل آلا (با وزن متوسط 32±463 میلی گرم) با جیره (تیمار Tau-1) حاوی 106*1 CFL/ml، (تیمار Tau-2) حاوی 107*1 CFL/ml و (تیمار Tau-3) حاوی 108*1 CFL/ml در هر 100 گرم غذا مکمل سازی شد...
Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies upstream of abnormal tau behavior, including detachment from microtubules, phosphorylation at several disease-specific sites, and self-aggregation into toxic tau species in AD brains. To prevent the cascade of events leading to ne...
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