It is difficult to completely resect huge anterior chest wall keloids and then close the wound directly. We report here our retrospective analysis of our case series of patients with such keloids who underwent reconstruction with internal mammary artery perforator (IMAP) pedicled propeller flaps and then received postoperative high-dose-rate superficial brachytherapy. METHODS All consecutive ...

BACKGROUND Previous reports on the treatment of hypertrophic scars and keloids have not described clear algorithms for multimodal therapies. This article presents an evidence-based review of previous articles and proposes algorithms for the treatment and prevention of hypertrophic scars and keloids. METHODS The methodologic quality of the clinical trials was evaluated, and the baseline charac...

Despite numerous basic studies on wound healing, keloids remain difficult to treat because of a lack of effective preventive or treatment methods. They have ugly external appearances and hinder daily life activities, as they are occasionally accompanied by unbearable itchiness or pain. In particular, if they occur in exposed areas of the face or upper and lower limbs, they will induce cosmetic ...

Keloids, a pathological scar that is induced by the consequence of aberrant wound healing, still major global health concern for its unsatisfactory treatment outcomes. HIF-1α, main regulator hypoxia, mainly acts through some proteins or signaling pathways and plays important roles in variety biological processes. Accumulating evidence has shown HIF-1α played crucial role process keloid formatio...

Ear keloids are among the most challenging plastic surgery conditions and may have significant psychosocial impact for the patient. Their aesthetic considerations are serious and despite a variety of treatment options, they often proved to be recurrent. This paper reviews the management options of ear keloids available in literature up to date. Multiple therapeutic options are discussed, such a...

Keloids and hypertrophic scars are characterized by excessive deposition of dermal collagen with resultant scar tissue. This scar tissue is benign, non-contagious and sometimes accompanied by severe itching, sharp pains and changes in texture. In severe cases, it can affect movement of skin and may ulcerate. There are various lines of treatment of keloids and hypertrophic scars including nutrit...

Keloid is a benign fibroproliferative tissue growth that exceeds the initial wound margins. It caused by disruption in healing phase with increased fibroblast activity and excess collagen deposition. usually develops after trauma. Orthopedic surgery inevitably causes trauma will lead to formation of keloids few patients. Keloids can cause cosmetic functional problems, thus interfere person's qu...

Sir, Non-invasive skin bioengineering techniques are successful in monitoring the progress and response to treatment of various skin diseases. Recently, measurements of skin thickness, elasticity, blood ̄ow, trans-epidermal water loss and hydration were used for objective and quantitative assessment of the maturation of keloids and hypertrophic scars (1 ± 3) and their response to treatment with ...

The aim of this study was to assess the feasibility and efficacy of high-dose, single-fraction electron beam radiotherapy for therapy-resistant keloids. Before 2010, intractable keloids were treated at our institution with post-operative irradiation of 6-15 Gy in 3-5 fractionations. For convenience and cost effectiveness, we have changed our treatment protocol to high-dose single-fraction radio...

BACKGROUND The management of keloids and hypertrophic scars continues to be controversial. Experience of treating 58 such lesions, 58.62% of which were recurrent, is presented. METHODS Each lesion was subjected to surgical excision with intra-operative local injection of triamcinolone acetonide, followed by repeat injection of the same drug at weekly intervals for 2-5 weeks depending on the s...