The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n 40) was explored. When pantoprazole area under the plasma concentration versus time curve (AUC) was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically sig...

In the article A Sparse Sampling Algorithm for Near-Optimal Planning in Large Markov Decision Processes, Kearns et al show that there’re now theoratical boundary’s to solve an mdp with an infinite state space in a such a way that the running time has no dependency’s on the size of the statespace. To come to this conclusion they introduce an algorithm that uses a sparse look-a-head tree to selec...

The purpose of this research was twofold. First, to determine if eight Multidimensional Health Locus of Control types hypothesized by Wallston and Wallston (1982) existed. Second, to assess the reliability, validity, and clinical utility of the control types. Two investigations were conducted based on research procedures designed for the discovery of clusters. The first study involved the deriv...

We are interested in the problem of planning for factored POMDPs. Building on the recent results of Kearns, Mansour and Ng, we provide a planning algorithm for fac-tored POMDPs that exploits the accuracy-eeciency tradeoo in the belief state simplii-cation introduced by Boyen and Koller.