BACKGROUND The DevR(DosR) regulon is implicated in hypoxic adaptation and virulence of Mycobacterium tuberculosis. The present study was designed to decipher the impact of perturbation in DevR-mediated signaling on these properties. METHODOLOGY/PRINCIPAL FINDINGS M. tb complemented (Comp) strains expressing different levels of DevR were constructed in Mut1* background (expressing DevR N-termi...

Escherichia coli is the most common cause of community-acquired urinary tract infection (UTI). During murine cystitis, uropathogenic E. coli (UPEC) utilizes type 1 pili to bind and invade superficial bladder epithelial cells. UPEC then replicates within to form intracellular bacterial communities (IBCs), a process whose genetic determinants are as yet undefined. In this study, we investigated t...

Distributed software problems are often addressed with object-oriented solutions. Objects provide the benefits of encapsulation and abstraction that have proven useful in managing the complexity of sequential code. However, the management of distributed objects is typically by means of complex APIs, such as CORBA, DCOM, or Java RMI. The complexity of the APIs is itself a hurdle to the writing o...

BACKGROUND Antibiotic residues are being constantly identified in environmental waters at low concentration. Growing concern has been expressed over the adverse environmental and human health effects even at low concentration. Hence, it is crucial to develop a multi-residues analytical method for antibiotics to generate a considerable dataset which are necessary in the assessment of aquatic tox...

We construct set-valued right Kan extensions via a relative Yoneda Lemma.

We have just seen that the category ∆ is equivalent to the subcategory consisting of the [n]. As a result, a simplicial set X• is given by specifying sets Xn for each n ∈ Z≥0, together with maps Xn → Xm for each map [m] → [n] in ∆. These maps are required to satisfy compatibility conditions (i.e., form a functor). The set Xn is called the set of n-simplices of X•. Example 1.3. Let X be a topolo...

homotopy theory, preprint, 1997. 18. W. G. Dwyer and D. M. Kan, Simplicial localizations of categories, J. Pure Appl. Algebra

Amaç: Bu çalışmanın amacı kan basıncı ve şekeri değerleri açısından yetişkin yaş grubundaki gönüllü bireylerin değerlendirilmesi şekeri, değerlerinin birbirleriyle yaş, kilo boy gibi verilerle ilişkisinin ortaya konulmasıdır. 
 Gereç yöntem: çalışmada ….. şehrinde yaşayan bilinen herhangi bir hastalığı olmayan gönüllüler randomize yöntemle seçilerek açlık ölçümleri gerçekleştirilmiştir. Aç...