نتایج جستجو برای: kai1
تعداد نتایج: 194 فیلتر نتایج به سال:
KAI1 IS ENGAGED IN NDRG1-MEDIATED METASTASIS SUPPRESSION THROUGH ATF3-NFKB COMPLEX IN HUMAN PROSTATE CANCER Wen Liu, Megumi Iiizumi-Gairani, Hiroshi Okuda, Aya Kobayashi, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Fei Xing, Koji Fukuda, Vishnu Modur, Shigeru Hirota, Kazuyuki Suzuki, Toshimi Chiba, Masaki Endo, Tamotsu Sugai, and Kounosuke Watabe Department of Medical Microbiology, Immunology...
The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored cellular receptor (uPAR) promotes plasminogen activation and the efficient generation of pericellular proteolytic activity. We demonstrate here that expression of the tetraspanin CD82/KAI1 (a tumor metastasis suppressor) leads to a profound effect on uPAR function. Pericellular plasm...
We have used microcell fusion-mediated chromosomal transfer to introduce normal human chromosomes into highly metastatic rodent prostatic cancer cells to map the location of a metastasis suppressor gene(s). Using this approach, several chromosomal regions have been identified that harbor such metastatic suppressor genes, including human chromosome 11 between p11.2-13 (T. Ichikawa et al., Cancer...
Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a transmembrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain (AICD) in the cytoplasm. In vitro and in vivo studies have implicated the role of AICD in cell signaling and transcriptional regulation of Gsk3β, KAI1, BACE1, EGFR, and other proteins. In this study,...
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
Pontin (Pont) and Reptin (Rept) are paralogous ATPases that are evolutionarily conserved from yeast to human. They are recruited in multiprotein complexes that function in various aspects of DNA metabolism. They are essential for viability and have antagonistic roles in tissue growth, cell signalling and regulation of the tumour metastasis suppressor gene, KAI1, indicating that the balance of P...
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