Aquilaria subintegra, locally known as "Gaharu", belongs to the Thymelaeceae family. This plant's leaves have been claimed to be effective for the treatment of Alzheimer's disease (AD) by Malay traditional practitioner in Malaysia. In this research, the chloroform extracts of the leaves and stem of A. subintegra were tested for acetylcholinesterase (AChE) inhibitory activity. The Thin Layer Chr...

In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, and the e...

The major flavonoids of Pisum are derivatives of kaempferol and quercetin, including both triglucosides and acylated triglucosides in which the acyl group is p-coumaric acid. Although hydroxycinnamic acid esters of flavonoids are common pigments in many plants, neither the enzymes nor the precursors involved in their biosynthesis have been demonstrated. We report here that crude enzyme preparat...

M. Veit3*, F.-C. Czygan3, L. Witteb, K. R. Markhamc, H. Geigerd a Lehrstuhl für Pharmazeutische Biologie, Universität Würzburg, Mittlerer Dallenbergweg 64, D-97082 Würzburg b Institut für Pharmazeutische Biologie, Technische Universität Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig c Industrial Research Limited, Petone, New Zealand d FB 13, Botanik, Universität des Saarlandes, D-66041...

Chromatographic separation of a 70% aqueous methanol extract (AME) of Pongamia pinnata (Linn.) Pierre (Leguminosae) leaves has led to the isolation of two new isoflavonoid diglycosides, 4'-O-methyl-genistein 7-O-beta-D-rutinoside (2) and 2',5'-dimethoxy-genistein 7-O-beta-D-apiofuranosyl-(1"'-->6")-O-beta-D-glucopyranoside (6), and a new rotenoid, 12a-hydroxy-alpha-toxicarol (5), together with ...

A phytochemical investigation of Allium tuberosum Rottler afforded two new phenylpropane glycosides, named tuberonoid A (1) and B (2), along with four known flavonoids, kaempferol 3-O-β-sophoroside (3), 3-O-β-D-(2-O-feruloyl)-glucosyl-7,4'-di-O-β-D-glucosylkaempferol (4), 3-O-β-sophorosyl-7-O-β-D-(2-O-feruloyl)glucosyl kaempferol (5), kaempferol 3,4'-di-O-β-D-glucoside (6). The identification a...

Two new prenylated flavonoids, named scariosin (1) and isorhynchospermin (2) were isolated from the leaves of paracalyx scariosa together with kaempferol, quercetin, kaempferol 3-O- rutinoside and rutin. The structures of (1) and (2) were characterized as 8-C- prenyl- taxifolin 7,3'-dimethylether and 6-C-prenylquercetin 7,4'-dimethylether by their chemical and spectra data, respectively.

The ability to form biofilms on surfaces makes Staphylococcus aureus the main pathogenic factor in implanted medical device infections. The aim of this study was to discover a biofilm inhibitor distinct from the antibiotics used to prevent infections resulting from S. aureus biofilms. Here, we describe kaempferol, a small molecule with anti-biofilm activity that specifically inhibited the forma...

Reducing sugar, 2-deoxy-D-ribose (dRib), produces reactive oxygen species through autoxidation and protein glycosylation and causes osteoblast dysfunction. Kaempferol, a natural flavonoid, was investigated to determine whether it could influence dRib-induced cellular dysfunction and oxidative cell damage in the MC3T3-E1 mouse osteoblastic cell line. Osteoblastic cells were treated with 30 mM dR...

The accumulation of kaempferol was evaluated in undifferentiated callus of Tylophora indica through TLC, HPTLC analysis with standard reference compound. Kaempferol is a strong antioxidant and help to prevent oxidative damage to our cells, lipids and DNA. In the present investigation, we have enhanced the kaempferol content in Tylophora indica tissue culture by using precursors like sallicyclic...