Hargreaves (1958), in a study of a population in Cornwall, England, noticed that a group of women with rheumatoid arthritis had fewer children than a control group without this disease. Independently, at this Unit, we have noticed that, of the large number of married women attending with rheumatoid arthritis, the majority had few children or none at all. Accordingly a controlled study was under...

CONTEXT Patients with refractory juvenile idiopathic arthritis can benefit from aggressive therapy. CASE REPORT We followed the clinical course of 4 patients (2 male, 2 female) aged 9.1-17.8 years (mean of 14.5 years) with polyarticular onset of juvenile rheumatoid arthritis and one 16-year-old boy with juvenile spondyloarthropathy associated with inflammatory bowel disease. All the juvenile ...

With advancing therapeutic options, achieving a state of remission has become the treatment goal in rheumatoid arthritis. Agreeing on what constitutes remission and what measures should be used to assess disease activity has remained a challenge. Multiple remission criteria have been devised and modified, all with different strengths and limitations. A consensus definition of remission will nee...