IjB proteins are known as the regulators of NF-jB activity. They bind tightly to NF-jB dimers, until stimulus-responsive N-terminal phosphorylation by IKK triggers their ubiquitination and proteasomal degradation. It is known that IjBa is an unstable protein whose rapid degradation is slowed upon binding to NF-jB, but it is not known what dynamic mechanisms control the steady-state level of tot...

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INTRODUCTION Amnesia or loss of memory is the cardinal hallmark of Alzheimer's disease (AD), a progressive neurodegenerative disorder associated with ageing process. Although, AD had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. However, there has been a growing interest in the use of phytomedicines with mu...

Este estudo teve como objetivo analisar as ações de enfrentamento à violência contra mulheres realizadas pela equipe multiprofissional da Secretaria Mulher Garanhuns (SecMul) e pelo Centro Especializado Atendimento mulher em situação – Joana Beatriz Lima Silva (CEAM-JB). Trata-se uma pesquisa que parte perspectiva construcionista do conhecimento das epistemologias feministas. A partir dos resul...

We revise the concept of compact tripotent in the bidual space of a JB*-triple. This concept was introduced by Edwards and Rüttimann generalizing the ideas developed by Akemann for compact projections in the bidual of a C*-algebra. We also obtain some characterizations of weak compactness in the dual space of a JC*-triple, showing that a bounded subset in the dual space of a JC*-triple is relat...

BACKGROUND Jolkinolide A (JA) and Jolkinolide B (JB) are diterpenoids extracted from the roots of Euphorbia fischeriana Steud and have been shown to have anti-tumor activity. However, their effects on the ability of tumor cells to invade blood vessels and metastasize remain largely unknown. Investigations into the effects of JA and JB on the angiogenesis of tumor tissues may facilitate the iden...