Defects in the Notch pathway ligand Dll3 have been identified in the mouse pudgy (Dll3(pu)) and human spondylocostal dysostosis (SD, MIM 277300) mutations. Although these mutations are primarily associated with segmental defects in the axial skeleton and somitic patterning, they also exhibit cranial neurological defects. Therefore we have looked at the expression of Dll3 in the developing mouse...

Although some of them may remain asymptomatic, congenital vertebral anomalies lead to spinal deformity and scoliosis. However they are relatively rarely seen in the cervical vertebrae [1]. We present a 10-year-old patient with several coexistent vertebral anomalies affecting the craniovertebral junction and upper vertebrae, which we believe to be a didactic example to the imaging anatomy of the...

Posterior mediastinal enteric cysts are infrequently reported. They are mostly asymptomatic 1. The incidence of gastroenteric cysts presenting during immediate neonatal period is rare. Alimentary tract duplications are other rare congenital anomalies and are commonly seen in relation to the ileum. However, the high incidence of associated thoracic or cervical vertebral anomalies with foregut cy...

BACKGROUND Goldenhar syndrome, also known as oculo-auriculo-vertebral spectrum (OAV) is a rare disorder in which the facial and vertebral anomalies are frequently associated with cardiac and pulmonary defects. The syndrome was first described by Dr. Maurice Goldenhar in 1952. The abnormalities usually involve one side of the body, and may range from mild to severe. While the deformities of the ...

A study of spondylolysis and spondylolisthesis in 142 children and adolescents is reported. In twelve of the seventy-nine patients followed for over a year the affected vertebra slipped further by 10 per cent or more. Increasing slip occurred mainly during the adolescent growth spurt, and was greater when spinal bifida or other vertebral anomalies were present. If at presentation the slip is le...

Introduction: Morphometric measurements including the weight of foetal spinal cord is helpful in determining the age and sex of foetuses, which are of great medicolegal significance. The aim of present study is to obtain accurate measurements of weight of human foetal spinal cord in different age groups. Material and Methods: Foetuses without any congenital cranio-vertebral anomalies were selec...

This book represents the first single volume in the English language dealing with procedures aimed at the accurate measuring of the female pelvis and the fetal head in utero. Because of the unreliability of the usual external pelvic measurements the obstetrical studies of recent years have tended to neglect this fundamental part of obstetrics. Indeed, until the advent of the Roentgen mensuratio...

Human remains have excited the curiosity and interest of the general public for centuries but their systematic study, and that of the diseases whose marks they bear, has been erratic and most often a fringe activity of those whose professional interests were directed mainly elsewhere. The first palaeopathological report appears to have been that of Esper' who described a tumour in the femur of ...