background: according to previous studies there are some different opinions on the pre-emptive effects of paracetamol in controlling post-operative pain, we aimed to compare the analgesic effects of pre-emptive paracetamol with post-operative paracetamol and morphine in patients undergoing septorhinoplasty. materials and methods: a hundred and six patients aged 15 to 50 were divided into 3 grou...

conclusions in the first one hour, diclofenac suppository is able to control the fever more efficient than paracetamol suppositories. results the average rectal temperature in the paracetamol group was 39.6 ± 1.13°c, and 39.82 ± 1.07°c in the diclofenac group (p = 0.37). the average rectal temperature, one hour after the intervention, in the paracetamol and the diclofenac group was 38.39 ± 0.89...

Treatment of paracetamol intoxication consists of administration of N-acetylcysteine, preferably shortly after paracetamol ingestion. In most countries, the decision to treat patients with N-acetylcysteine depends on the paracetamol plasma concentration. In the literature, different arguments are given regarding when to treat paracetamol overdose. Some authors do not recommend treatment with N-...

OBJECTIVE To determine whether non-pharmaceutical retail outlets are aboding to the current Medicines and Healthcare products Regulatory Agency (MHRA) national guidelines for over-the-counter (OTC) sales of aspirin and paracetamol. METHODS Stages 1 and 2 of the study deployed eight and four medical students, respectively, to undertake a mystery shopper style investigation. Stage 1: eight medi...

The effects of caffeinated and non-caffeinated paracetamol administration, with or without vitamins A and E supplementation on the protein and enzyme levels in Wistar albino rats were investigated using caffeinated paracetamol and paracetamol as caffeinated and non-caffeinated paracetamol respectively, and water soluble acetic acid derivatives of vitamins A and E. Serum AST, ALT and ALP levels ...

Paracetamol has always been regarded as a useful and safe drug. The risk of toxicity with repeated supratherapeutic paracetamol is an underrecognised condition. We report on a 12-month-old boy who presented with hepatotoxicity, disseminated intravascular coagulation and persistent renal insufficiency 4 days after repeated ingestion of a supratherapeutic dosage of paracetamol. To the best of our...

Paracetamol was polymerized in a reaction mixture containing xanthine oxidase, xanthine and paracetamol. This polymerization reaction was not inhibited by allopurinol or KCN, indicating that neither the molybdenum sites nor the iron-sulphur centres of the enzyme were involved in this catalytic activity. Removal of the flavin centres from the enzyme, however, completely abolished paracetamol oxi...

OBJECTIVE To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions. DESIGN Database searches were conducted to identify double-blind trials comparing paracetamol/caffeine with paracetamol alone (benefit analysis) and any data pertaining to hepatotoxicity of paracetamol when combined with caffeine (risk analysis). INTERVENTION...

OBJECTIVE To investigate the relationship between the availability of paracetamol and its use for overdose and suicide. DESIGN Analysis of routinely collected information on time trends for paracetamol suicides, non-fatal overdoses, and sales. SETTING England and Wales and France. RESULTS There were strong correlations between trends in paracetamol sales in the UK and trends in non-fatal ...