The extent of decreases in apparent hepatic clearance and intrinsic hepatic clearance of midazolam (MDZ) after intravenous administration of MDZ with concomitant oral administration of cimetidine (CIM), itraconazole (ITZ), or erythromycin (EM) was predicted using plasma unbound concentrations and liver unbound concentrations of inhibitors. When MDZ was concomitantly administered with CIM, the o...

This study models concrete as a multi-phase system that comprises the mortar, coarse aggregates, and interfacial transition zones (ITZs). The diffusivity volumetric fraction of these phases are considered to propose three-phase diffusion–reaction model simulate external sulphate attack. Furthermore, parametric analysis alongside sensitivity is carried out quantify effect on expansive cracking i...

Concrete with siderurgical aggregates (SA) is a sustainable construction material great potential as structural concrete. For this reason, studies must be carried out on the behavior of concrete against prestressed elements, that open door to new applications such buildings, bridges or foundations. In study, feasibility established standardized adherence tests beams reinforced steel wires. The ...

This paper systematically investigates the micromechanical properties of interfacial transition zone (ITZ) in alkali-activated fly ash-slag (AAFS) concrete using nanoindentation, backscattered electron microscopy and energy dispersive spectroscopy. Results indicate that ITZ depend on chemical composition reaction products its microstructural characteristics. The with high proportion N-C-A-S-H C...

Sir, Cryptococcus neoformans, an ubiquitous soil yeast, causes neurological and /or disseminated mycotic invasion and is the fourth most common infection in AIDS patients. ~ Conventional treatment of cryptococcosis [amphotericin B (AMB) with flucytosine] is not completely satisfactory in such patients because of persistent immune defects and frequent toxicity of these antifungal drugs. For thes...

In this research, we developed a four-phase model, which takes the aggregate gradation and porosity into account in prediction of elastic modulus concrete, based on micromechanical theories. The model has been verified with experimental results. First, using Mori Tanaka differential self-consistent (DSC) methods, pores both mortar interfacial transition zone (ITZ) were homogenized. Then, contin...

Dumped construction waste (municipal solid waste) is a major threat to the environment in recent times due its abundance generation resulting from increased activities. Perhaps, scarcity of materials also alarming urbanization necessitating an alternative suitable material. Concerning above complications, this research encompasses sustainable use concrete fractions as replacement for natural fi...