Ins(1,3,4,5)P4 was able to mobilize the entire Ins(1,4,5)P3-sensitive intracellular Ca2+ store in saponin-permeabilized SH-SY5Y human neuroblastoma cells in a concentration-dependent manner, yielding an EC50 value of 2.05 +/- 0.45 microM, compared with 0.14 +/- 0.03 microM for Ins(1,4,5)P3. However, L-Ins(1,3,4,5)P4 [= D-Ins(1,3,5,6)P4] failed to cause mobilization of intracellular Ca2+ at conc...

The firing properties of single spinal interneurons (INs) were studied in five awake, behaving monkeys performing isometric or auxotonic flexion-extension torques at the wrist. INs tended to fire tonically at rest (mean rate, 14 spikes (sp)/sec) and during generation of static torque (mean rate, 19 sp/sec in flexion, 24 sp/sec in extension). INs exhibited regular firing, with autocorrelation fu...

IL-1a, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1a rs3783553) in the 3' UTR of IL-1a may disrupt a binding site for miRNA-122 and may affect its transcription level. Thus, this polymorphism may cause interindividual variation in immune and inflammation responses and th...

Proinsulin-transferrin (ProINS-Tf) fusion protein was evaluated for its in vivo pharmacokinetics, efficacy, and mechanism. Our previous studies have shown that ProINS-Tf was converted to active insulin-transferrin (INS-Tf) via the transferrin (Tf)-receptor-mediated pathway in hepatoma cells. We hypothesized that this fusion protein can be administered as a prodrug and be converted to a biologic...

(‘Oflsbinsed cytopensias, ins which nsore than one blood cell type is affected its the sanse individual, are of imsterest.. Ats anstileukocyte factor has recenutly heems demonust.rated ins sonse cases of pancyt.openia. Ins the case of IKissnuseyer-Nielsen6 and in that of Moeschlins7 the evidence vas derived from transfusions experimenits. Dausset8 usinsg the ins vitro agglutimsations metho.d fo...

We developed a novel inflammation-nutrition scope (INS) based on systemic inflammatory response and nutritional status, and explored its prognostic value in hepatocellular carcinoma (HCC), especially for those with early-stage disease.The INS was developed based on a retrospective study of 185 patients with HCC undergoing hepatectomy between 2006 and 2007, and validated in a prospective study o...

Positional isomers of D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), Ins(1,4,6)P3, and Ins(1,3,6)P3 were examined to explore the roles for hydroxyl groups of Ins(1,4,5)P3, recognized by metabolic enzymes and by the receptor. Ins(1,4,6)P3 and Ins(1,3,6)P3 inhibited the dephosphorylation of [3H] Ins(1,4,5)P3 by the 5-phosphatase present in erythrocyte ghosts. The Ki value for the former compo...

In present scenario GPS is widely used to provide extremely accurate position information for navigation. From, where the GPS does not give continuous localization in environments where signal blockages are present, Inertial Navigation System comes into action. Because of sensors present in INS and time integration process, errors get accumulated over time. Henceforth, an aiding system is integ...

Accuracy and robustness are vital to present and future air navigation, both in the military and civil spheres. The strengths of INS and GPS are well known; integrated INS/GPS systems combine their advantages. However, the knowledge required to jam GPS is becoming public, and it can be carried out with basic hardware. When GPS data are unavailable, and a low grade INS is used, navigation accura...