In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5),...

BACKGROUND Radial artery (RA) aortocoronary bypass grafts anastomosed to a branch of the circumflex coronary artery have significantly better patency rates than saphenous vein (SV) grafts at 5 years, but the physiological characteristics and mechanisms involved are not clearly defined. We compared RA and SV graft vasomotor and flow responses to endothelium-dependent and -independent stimuli 5 y...

The present study evaluated the beneficial effect of aqueous extract of garlic (Allium sativum L.; 100mg/kg/day) on the alterations in vascular reactivity of streptozotocin-diabetic rats. After 8 weeks of treatment, thoracic aortic rings of rats were mounted in organ baths and contractile responses to phenylephrine and relaxant responses to acetylcholine and isosorbide dinitrate were assessed. ...

AIMS This study aims to visualize ultrasonically deformation of atherosclerotic plaques in human coronary arteries during vasoconstriction and vasodilatation. METHODS AND RESULTS Intravascular ultrasound detected occult atherosclerosis in angiographically normal coronary arteries of eight patients with chest pain at rest. During the acetylcholine provocative test, intravascular ultrasound mon...

1. BM 12.434 was compared with a known beta-adrenoceptor-blocking agent, metipranolol, and a combination of metipranolol and isosorbide-5-mononitrate in healthy volunteers. BM 12.434 and metipranolol were given in equi-effective beta-adrenoceptor-blocking doses (reduction of exercise-increased pulse--pressure product). 2. Responses of the cardiovascular system were determined by non-invasive me...

This paper reports the experiences of the second clinical trial in the use of isosorbide in the treatment of 34 selected cases of infantile hydrocephalus of all types. Subject to careful biochemical monitoring of serum electrolyte, urea, and acid-base balance, treatment with 2 g/kg body weight 6-hourly is safe. Side effects are immediately eliminated by interrupting therapy. With lower dosage, ...

The purpose of this study was to identify bioactive compounds Beauveria bassiana entomopathogenic fungi derived from insect isolates Leptocorisa oratorius and endophytic B. cocoa plants that have bioactivity as growth boosters. research conducted in the laboratory Biological Control, Faculty Agriculture, Andalas University. for 4 months, using GCMS method. From results study, identified booster...

This study was designed to determine the extent, to which isosorbide-5-mononitrate (5-ISMN) contributes to the hemodynamic effect of isosorbide dinitrate (ISDN) in conscious dogs. Test drugs (ISDN or 5-ISMN) were given orally. Either ISDN or 5-ISMN produced a decrease in blood pressure dose-dependently, the decrease in pulse pressure being specific; the pattern of blood pressure change induced ...

berg A, et al. Diagnosis and management of out-of-hospital cardiac arrest secondary to coronary artery spasm. Resuscitation. 2003;58:145-52. 2. Karch SB. Coronary artery spasm induced by intravenous epi-nephrine overdose. High dose nitroglycerin treatment in a patient with cardiac arrest: a case report. A. Recurrent catecholamine-induced coronary vasospam treated by intracoronary injection of i...