In the Speedwell study set up to examine primarily the relation of plasma lipids and ischaemic heart disease in men aged 45 to 64 years drawn randomly from the practices of 16 general practitioners, various haemostatic factors which may contribute both to thrombogenesis and atherogenesis were measured. Fibrinogen measured nephelometrically and plasma viscosity were positively associated with th...

OBJECTIVE To test the hypothesis that sleep disorders are relevant to the risk of ischaemic stroke and ischaemic heart disease events in older men. DESIGN A cohort study. SETTING The Caerphilly cohort, a representative population sample of older men in South Wales, UK. PARTICIPANTS 1986 men aged 55-69 years completed a questionnaire on sleep patterns with help from their partners. This as...

Lipoprotein patterns were estimated by membrane filtration and nephelometry in a random sample of men aged 30 to 69years and in an age-matchedgroup of male patients with ischaemic heart disease. The lipoprotein patterns were classified according to the SML classification. Significantly abnormal lipoprotein patterns were found in 20 per cent of the random sample and 40 per cent of the ischaemic ...

Ischaemic heart disease accounts for nearly half of the global cardiovascular disease burden. Aetiologies relating to heart disease are complex, but dyslipidaemia, oxidative stress and inflammation are cardinal features. Despite preventative measures and advancements in treatment regimens with lipid-lowering agents, the high prevalence of heart disease and the residual risk of recurrent events ...

Background: This study investigated the effects of age, gender, socio-economic status, smoking hypertension, ischaemic heart disease, Body Mass Index (BMI), Glycaemic control (HbA1c) and dyslipidaemia in type 2 diabetes a population-based analysis.

OBJECTIVE The aim of this study was to investigate the interaction between cardiovascular disease severity and OA co-morbidity on physical health. METHODS A baseline questionnaire was mailed to 9676 patients aged ≥40 years from UK family practices. A priori exclusive morbidity groups were constructed as follows, based on records 3 years before baseline: (i) reference group--neither cardiovasc...

Myocardial ischaemia may result from congenital abnormalities in the origin or distribution of the coronary arteries. Coronary obstruction may also develop at a young age in some rare hereditary disorders such as Hurler's syndrome, homocystinuria or pseudoxanthoma elasticum. The coronary arteries may be the site of embolism; ostial stenosis may complicate luetic (or other) aortitis or coronary ...

The overwhelming dominance of the lipid hypothesis for atheroma has obscured the compelling evidence-some of it of many years standing' but some that is more recent2 3 -that both platelets and the coagulation system also contribute to the lesion. There is much epidemiological evidence4 5 of some other process besides atherogenesis to account for the clinical manifestations of coronary artery di...

There is evidence from population studies of strong positive associations between smoking, arterial pressure and serum cholesterol concentration and risk of ischaemic heart disease, and these appear to be independent of one another, but the evidence from unifactorial trials of risk factor reduction is less impressive. For smoking, there is no good experimental evidence that cessation reduces th...