Technical iodine was found to catalyze the condensation between 2-aminobenzohydrazide (1) and some aldehydes and ketones in absolute ethanol under mild conditions to afford hydrazone and quinazoline derivatives, respectively. Condensation of 1 with terephthalaldehyde (2) in 1 : 1 molar ratios afforded the hydrazone 3, while hydrazone 4 was formed on using a double molar ratio of 1. On the other...

The V(V) atom in the title complex, [V(C(14)H(8)BrClN(2)O(2))(CH(3)O)O(CH(3)OH)], is six-coordinated by one phenolate O, one imine N and one enolic O atom of the hydrazone ligand, one oxide O atom, one methanol O atom and one methoxide O atom in a distorted octa-hedral geometry. The dihedral angle between the two benzene rings of the hydrazone ligand is 13.2 (3)°. The deviation of the V atom to...

isatin, n-methyl isatin and n-benzylisatin were smoothly monobrominated in the 5-position by treatment with pyridinium bromochromate (pbc) in acetic acid medium. in the similar conditions indigo underwent bromination and oxidation to give 5-bromoisatin in high yield.

Schiff base condensation of benzil bis(hydrazone) with formaldehyde, acetone and benzaldehyde and its nickel(II) complexes were synthesised. Preparation of the free ligands was accomplished by refluxing benzil with hydrazine derivatives in 1:10 mole ratios in ethylene glycol. The spectral characterisation of hydrazone based 14-membered octaaza macrocyclic complexes of nickel(II) was undertaken....

The NMR spectra of azo dyes, 5-arylazobarbituric (5a-g), 5-arylazo-1,3-dimethylbarbituric(6a-g) and 5-arylazothiobarbituric acids (7a-g) were studied in DMSO-d6 in differentconcentrations. An intramolecular hydrogen bond was observed and indicating that thehydrazone forms is mostly predominant. The peak of the hydrazone proton was severelybroadened and its chemical shift appeared at down field ...

In the title isatin compound, C(16)H(18)N(2)O(6), the pyrrolidine ring adopts an envelope conformation and is inclined at a dihedral angle of 7.31 (5)° with respect to the benzene ring. The acetyl group is disordered over two positions with refined occupancies of 0.503 (4) and 0.497 (4). These groups make dihedral angles of 12.6 (6) and 19.6 (7)° with the pyrrolidine ring. In the crystal struct...

The effects of isatin (2,3-dioxo-indole) and isatin analogues (5-methylisatin, 6-hydroxyisatin, 7-ethylisatin, N-acetylisatin) were tested on prostaglandin E2 (PGE2)-induced fever in mice and rats. Two modes of administration were tested. Isatin or an analogue was injected simultaneously with PGE2 and the development of fever was tested, or the test compound was given 30 min following PGE2 admi...

Room temperature zinc-mediated diastereoselective allylation or propargylation of isatin-derived N-tert-butanesulfinyl ketimines for synthesis of highly enantiomerically enriched tetrasubstituted 3-aminooxindoles is described.

A novel phosphine-catalyzed highly diastereoselective [3+2] cycloaddition of isatin derived α,β-unsaturated ketones with α-allenic ester has been developed.