Our previous research have identified a series of N-phenyl substituted isatin derivatives as antitumor agents in vitro. 5-Bromo isatin derivatives have been found to increase their cytotoxic activity and selectivity. A series of 5-bromo-N-phenyl isatin analogues were designed and synthesized about 40-80% overall yields. All of synthesized compounds have not been reported before. Their structure...

some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform with (E)-5-styrylisatin being the most potent inhibitor. To further investigate these structure-activity relationships (SAR), in the present study, additional C5- and C6-subst...

Marine organisms such as seaweeds, sponges and corals protect their own surfaces from fouling by their high anesthetic, repellant, and settlement inhibition properties. Within the marine ecosystem, evolution has allowed for the development of certain antifouling properties. Isatin is a biologically active chemical produced by an Alteromonas sp. strain inhibiting the surface of embryos of the ca...

The preparation of palladium(II) complexes of 3,5-diacyl-1,2,4-triazole bis(thiosemicarbazone) (H2L2), 2,6-diacylpyridine bis(thiosemicarbazone) (H2L3) and benzyl bis(thiosemicarbazone) (H2L4) is described. The new complexes [PdCl2(H2L2)] (1), [PdCl2(H2L3)] (2) and [PdL4].DMF (3) have been characterized by elemental analyses and spectroscopic studies (IR, 1H NMR and UV-Vis). The crystal and mol...

The palladium(II) bis-chelate complexes of the type [Pd(TSC(1-5))2] (6-10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC(1) (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC(2) (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC(3) (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC(4) (4), and 4-phenyl-1-(1'-nitro-2'-naphtha...

An exceptionally mild method for the preparation of isatin derivatives has been developed using a sulfur ylide mediated carbonyl homologation sequence starting from anthranilic acid precursors. This method proceeds at ambient temperature via a sulfur ylide intermediate without the need for protection of the amine or chromatographic isolation of the intermediate ylide. Gentle oxidation of the su...

A square planar copper complex of derivatized NSAID drug (Ketoprofen thiosemicarbazone [3-benzoyl-alpha-methyl benzene acetic acid thiosemicarbazone]), is characterized by elemental analysis, spectroscopy, electrochemistry and magnetic susceptibility studies which exhibits dose-dependent and enhanced antiproliferative effects on human breast cancer cell line T47D rich in progesterone receptors.

Isatin, previously shown to promote growth in green and etiolated pea stems, is converted mainly to anthranilate in those tissues; small quantities of isatate are also formed. Fed anthranilate is converted mainly to its beta-d-glucoside; smaller amounts are metabolized to anthranilamide, tryptophan and kynurenine. These data provide some basis for understanding the growth promoting activity of ...