Upper airway irritation and airflow limitation have been reported in mice during single exposures to the oxidation products (OPs) of isoprene, a hemiterpene emitted by humans and vegetation. This study evaluated the respiratory effects of repeated exposures to isoprene OPs. Male mice of 6 strains were exposed to a reaction mixture comprised of 3227 ± 157 ppm isoprene and 1080 ± 155 ppm ozone 3 ...

OBJECTIVES Phlebotomists occupationally exposed to isopropanol (IPA) (2-propanol) and naïve controls (n = 12 per group) were exposed to the time-weighted average threshold limit value of 400 p.p.m. IPA for 4 h in an environmental chamber to investigate: (i) acute effects of sensory irritation using subjective health symptom reports and objective, physiological end-points; and (ii) differences i...