Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine re...

conclusions in conclusion, the persian version of the ibs-qol provided a well-defined measure of qol in ibs patients with high validity and reliability that is an appropriate measure to use in further ibs clinical studies in iran. patients and methods the original 34 items of the ibs-qol were translated from english into persian through a structured procedure for the translation and cultural ad...

background: irritable bowel syndrome (ibs) is a common disease; it seems that psychological factors play a role in development and maintenance of ibs. the main purpose of the current study is to compare patients with ibs and healthy individuals regarding anxiety, sensitivity, and neuroticism. materials and methods: participants included 76 ibs patients (41 female and 35 male) who referred to th...

personality traits and emotion regulation processes play an important role in human health. the purpose of this study was to investigate the role of positive personality traits (psychological hardiness and interpersonal forgiveness) in emotion regulation of patients with irritable bowel syndrome.the research was a cross-sectional study. statistical population included all of ibs patients referr...

introduction and aim: gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are important diseases, which are increasing in frequency and capable of impairing the quality of life to the same extent or even more than severe organic gastrointestinal diseases. these disorders have a significant burden on the health care system. the aim of this study was to determine the prevale...

background: to compare the efficacy of metronidazole versus placebo in the control of gaseous symptoms inpatients with functional bowel disease. materials and methods: in the absence of organic or systemic diseases, all cases with chief complaints of bloating and normal laboratory tests were consecutively enrolled in this double-blind study. lactase deficiency and bacterial overgrowth were rule...

background irritable bowel syndrome is one of the most common gastrointestinal disorders characterized by chronic abdominal pain, altered bowel habits or changes in stool consistency. unfortunately, no specific treatments for relieving  ibs symptoms have been suggested yet. this pilot study was conducted to evaluate the efficacy of the cumin extract, a kind of herbal used in the treatment of ga...

external exposed radiation may play an important role in pathogens of irritable bowel syndrome (ibs), although is thought to arise due to a combination of genetic and environmental factors. the result is dysregulated immune responses due to alteration in the gut microbiota population and the subsequent development of gut inflammation. it has recently been shown that the effect of ionizing radia...

irritable bowel syndrome (ibs) is one of the most common gastrointestinal disorders particularly affecting the quality of life (qol). evaluating qol in ibs patients is a valuable method of defining a psychobiological pattern of disease. various disease specific and general instruments are now available to measure health-related qol (hrqol) in ibs patients. though, no comparison has been made be...