نتایج جستجو برای: iron profile
تعداد نتایج: 361179 فیلتر نتایج به سال:
We present the results of an ASCA observation of the LINER NGC 4579. A point-like X-ray source is detected at the nucleus with a 2–10 keV luminosity of 1.5× 1041 ergs s−1assuming a distance of 16.8 Mpc. The X-ray spectrum is represented by a combination of a power-law with a photon index of ∼1.7 and soft thermal component with kT ∼0.9 keV. An iron K emission line is detected at 6.73 ± 0.13 keV ...
OBJECTIVES Study the profile of behavior and intelligence of children with anemia and their possible association to the hematological parameters. METHODS Fifty-eight children (42 anemic; 16 controls), matched by age, sex, and culture with the patients, were subjected to both behavioral and IQ testing using Revised Behavior Problem Checklist (RBPCL) and Wechsler intelligence scale for children...
This paper is dedicated to the memory of our wonderful colleague Professor Alfredo Colonna, who passed away the same day of its acceptance. Fatty liver accumulation, inflammatory process and insulin resistance appear to be crucial in non-alcoholic fatty liver disease (NAFLD), nevertheless emerging findings pointed an important role also for iron overload. Here, we investigate the molecular mech...
Carcinogenesis is a multistep process. Besides somatic mutations in tumor cells, stroma-associated immunity is a major regulator of tumor growth. Tumor cells produce and secrete diverse mediators to create a local microenvironment that supports their own survival and growth. It is becoming apparent that iron acquisition, storage, and release in tumor cells is different from healthy counterparts...
Diabetic nephropathy (DN) remains incurable and is the main cause of end-stage renal disease. We approached the pathophysiology of DN with systems biology, and a comprehensive profile of renal transcripts was obtained with RNA-Seq in ZS (F1 hybrids of Zucker and spontaneously hypertensive heart failure) rats, a model of diabetic nephropathy. We included sham-operated lean control rats (LS), sha...
Pulmonary iron excess is deleterious and contributes to a range of chronic and acute inflammatory diseases. Optimal lung iron concentration is maintained through dynamic regulation of iron transport and storage proteins. The iron-regulatory hormone hepcidin is also expressed in the lung. In order to better understand the interactions between iron-associated molecules and the hepcidin-ferroporti...
OBJECTIVES/METHODS This 1-yr prospective phase II trial evaluated the efficacy of deferasirox in regularly transfused patients aged 3-81 yrs with myelodysplastic syndromes (MDS; n = 47), Diamond-Blackfan anaemia (DBA; n = 30), other rare anaemias (n = 22) or beta-thalassaemia (n = 85). Dosage was determined by baseline liver iron concentration (LIC). RESULTS In patients with baseline LIC > or...
We present a detailed analysis of the iron Kα line variabilities in NGC 4151 by using long ASCA observation data obtained in May 1995. Despite the relatively small amplitude variations in the continuum flux, the iron Kα line flux and profile show dramatic variations. Particularly, the line profile changes from single peak to seeming double peaks and back in time scales of a few 10 4 sec. The se...
Oxidative damage is known to cause deleterious effects on cellular function leading to a number of disease conditions. Involvement of oxygen radical has been suggested in many clinical conditions including Coronary Heart Disease (CHD). The present investigation describes the lipid profile, trace element profile, SOD, catalase activity and lipid peroxidation in CHD patients in the age group betw...
BACKGROUND & OBJECTIVES While there is evidence of an altered immune profile in iron deficiency, the precise immunoregulatory role of iron is not known. Information particular in children who are vulnerable to iron deficiency and infection, is lacking. We undertook this study with the aim of documenting the changes in T cell subsets in children in the age group of 1 to 5 yr with iron deficiency...
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