BACKGROUND There is a need to determine whether iron absorption from iron amino acid chelates is protected from inhibition by dietary phytate and regulated normally by iron status. OBJECTIVE The objective of this study was to compare iron absorption from ferrous sulfate, ferrous bisglycinate, and ferric trisglycinate in whole-maize meal; to determine whether iron from ferrous bisglycinate and...

The behavior of rat transferrin has been investigated employing acrylamide gel electrophoresis and isoelectric focusing. In vitro trace labeling with iron chelates at 30 min was 93%-98% effective, whereas binding by simple ferric salts was reduced to 71%-76%. Complete and specific binding of 59FeSO4 by the iron binding sites of transferrin was demonstrated after in vitro or in vivo addition of ...

Recent studies demonstrate that dissolved iron in seawater is bound to strong organic complexes that have stability constants comparable to those of microbial iron chelates. We examined iron acquisition by seven strains of heterotrophic marine bacteria from a number of siderophore–iron complexes, including desferrioxamine B (DFB) and marine siderophores partially purified from iron-limited cult...

That ferritin, an iron storage protein, can be produced by neuroblas toma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neuroblastoma cell lines. Cells (5 x 10") were incubated with graded amounts of desf...

Mit Hilfe der Gelchromatographie wurde eine Bestimmungsmethode für Eisenchelate entwickelt, welche in der landwirtschaftlichen und gartenbaulichen Praxis angewandt werden kann. Das Verfahren wird als Standardmethode bei der Qualitätsprüfung von Handelspräparaten empfohlen. Die Eisenchelate wurden auf einem Gelbett von Sephadex G-10 aufgetrennt. Nach Eluierung konnten die Eisenchelate mittels ei...

Curcumin, a polyphenol derived from turmeric, is an ancient therapeutic used in India for centuries to treat a wide array of ailments. Interest in curcumin has increased recently, with ongoing clinical trials exploring curcumin as an anticancer therapy and as a protectant against neurodegenerative diseases. In vitro, curcumin chelates metal ions. However, although diverse physiological effects ...

Preliminary evidence suggested that phosphate or borate destabilize iron. ovotransferrin nitrilotriacetate complexes in the absence of added bicarbonate. The iron. ovotransferrin.EDTA complex was prepared in the absence of bicarbonate, and a number of anions, including phosphate, sulfate, and citrate, were found to perturb the visible absorbance (A,,,,, = 490 nm) of this complex. Other anions, ...

BACKGROUND Desferrioxamine (DFO) is an important iron chelating agent. It has also been thought of as an agent with anti-oxidant potential as it chelates ferric iron in various parts of the body. However, there is evidence suggesting that it may paradoxically affect red blood cells (RBC) by inducing intracellular oxidant stress. To further understand the mechanism of DFO's interaction with RBC,...

That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neuroblastoma cell lines. Cells (5 X 10(4)) were incubated with graded amounts of des...

Background A T1 nanoparticle contrast agent showing high r1 relaxivity is desired to provide more sensitive molecular/ cellular imaging with reduced Gd dose, and may have more clinical utility than T2* (e.g., iron-based) approaches. Tethering multiple Gd-chelates to a supramolecular platform is a promising strategy to increase r1 relaxivity, as rotational correlation time of the Gd ions can bec...