BACKGROUND There is a gap between the number of patients requiring a renal allograft and the number of potential deceased donors (DD). One alternative is using allografts from non-related living donors (NRLD). AIM To compare survival and complications of renal allograft recipients from DD, related living donors (RLD) and NRLD. MATERIAL AND METHODS Observational study of a cohort of renal al...

OBJECTIVES Donor age is a known risk factor for chronic allograft failure (CAF) in renal transplant recipients. We have recently shown that advanced recipient age is also a risk factor for CAF. To investigate the interaction between donor and recipient age, we analyzed 40,289 primary solitary Caucasian adult renal transplants registered at the United States Renal Data System (USRDS) from 1988 t...

Background. Primary focal segmental glomerulosclerosis (FSGS) is one of the commonest causes of glomerular disease and if left untreated will often progress to established renal failure. In many cases the best treatment option is renal transplantation; however primary FSGS may rapidly recur in renal allografts and may contribute to delayed graft function. We present a case of primary nonfunctio...

BACKGROUND Chemokines are involved in the recruitment of leukocytes to vascularized allografts. CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts. METHODS Formalin-fixed, paraffin-embedded allograft nephrectomies (n = 9) and non-involv...

Biopsy of the transplanted kidney may provide useful diagnostic and prognostic information [ljJ. Several biopsy methods have been developed to minimize the risk of damaging the solitary functioning renal allograft. Each method has inherent advantages and disadvantages. Recently, ultrasonography has provided a safe and efficient means of guidance for biopsy of native kidneys [2-6]. Because of pr...

Levels of BP have been associated with increasing rates of renal allograft failure from cadaveric donors, independent of renal function. The effect of BP, a modifiable risk factor, on the failure rates of renal allografts from living donors is unknown and maybe obscured by the rate of decline of renal function from this source of organs. A nonconcurrent cohort study collecting data from 392 rec...

Introduction: Determining if the cause of renal allograft dysfunction in the early post transplant period is due to rejection or other reasons is a daunting task for the clinician. Clinical signs and symptoms alone are not helpful in clearly distinguishing the numerous causes of renal dysfunction. Various noninvasive tests including imaging studies have also been unsuccessful in distinguishing ...

The incidence of renal allograft rupture in transplantation is between 0.3-9.6%. major causes rejection followed by acute tubular necrosis and vein thrombosis. We discuss a case secondary to antibody mediated rejection, its management, the patient outcome.