The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and norm...

BACKGROUND Warfarin is the most commonly used oral anticoagulant for the treatment and prevention of thromboembolic disorders. Pharmacogenomics studies have shown that variants in CYP2C9 and VKORC1 genes are strongly and consistently associated with warfarin dose variability. Although different populations from the Middle East and North Africa (MENA) region may share the same ancestry, it is st...

Wheat streak mosaic tritimovirus (WSMV) seriously damages wheat worldwide. We report analyses of new complete ORF (CO) sequences from seven Australian isolates with 56 COs and 128 coat protein (CP) genes sequenced previously. Eleven CO three CP were recombinants so removed our analyses. Patristic distances maximum-likelihood phylogenies nonrecombinant (n-rec) their closely correlated (R = 0.994...

This study was conducted to determine the effects of soil and climatic conditions on glycyrrhizic acid contents in various Iranian populations of Glycyrrhiza glabra in two root diameters. Twelve populations in arid, semi-arid and Mediterranean climates of different parts of Iran were collected and the content of glycyrrhizic acid was determined using HPLC. The results showed that contents of gl...

This study was performed to determine the genetic diversity of HLA class I and II alleles among two ethnic groups in Southeastern Iran. HLA profiles were determined in 71 Iranian populations (41 Zaboli and 30 Baloch). The frequencies of HLA-A02 (p=0.017), -Cw4 (p=0.003), and -DR8 (p=0.025) in the Zaboli populations were significantly higher than that in Baloch ethnic group. In contrast, the fre...