نتایج جستجو برای: ip and rs
تعداد نتایج: 16837129 فیلتر نتایج به سال:
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels that are located on intracellular Ca(2+) stores. We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT). Because IRBIT is released from IP(3)R by physiological concentrations of IP(3), we hypothesized that IRBIT is a signaling molecule that is released ...
PURPOSE To investigate endothelin 1 (Et1)-dependent Ca(2+)-signaling at the cellular and subcellular levels in retinal arteriolar myocytes. METHODS Et1 responses were imaged from Fluo-4-loaded smooth muscle in isolated segments of rat retinal arteriole using confocal laser microscopy. RESULTS Basal [Ca(2+)](i), subcellular Ca(2+)-sparks, and cellular Ca(2+)-oscillations were all increased d...
Bot-e-Gaz prospect area is located 34 km north of Torbate-e-Jam, Khorasan Razavi Province. Geology of the area includes diorite, granodiorite, and syenogranite intrusinos that intruded in metamorphic rocks. Magnetic susceptibility of intrusive rocks is <5× 10-5 SI and belong to ilmenite series (reduced type). These intrusive rocks are metaluminous to peraluminous and vary from medium potassium ...
The Allen-Bradley ControlLogix [1] line of programmable logic controllers (PLCs) offers several interfaces: Ethernet, ControlNet, DeviceNet, RS-232 and others. The ControlLogix Ethernet interface module 1756-ENET uses EtherNet/IP, the ControlNet protocol [2], encapsulated in Ethernet packages, with specific service codes [3]. A driver for the Experimental Physics and Industrial Control System (...
the aim of this study was to identify various sulfidic mineralized zones in the ghare-tappeh cu deposit (nw iran) based on geo-electrical data including induced polarization (ip) and resistivity (rs) using the concentration-volume (c-v) and number-size (n-s) fractal models. the fractal models were used to separate high and moderate sulfidic zones from low sulfidic zones and barren wall rocks. b...
RATIONALE Neuronal calcium sensor-1 (NCS-1) regulates various neuronal functions. Although it is expressed in the heart, very little is known about its cardiac functions. OBJECTIVE This study aimed to identify the physiological and pathological roles of NCS-1 in the heart. METHODS AND RESULTS We characterized the cardiac functions of knockout mice (Ncs1(-/-)) and identified NCS-1 as a novel...
Autophagy is a lysosomal degradation pathway that converts macromolecules into substrates for energy production during nutrient-scarce conditions such as those encountered in tumor microenvironments. Constitutive mitochondrial uptake of endoplasmic reticulum (ER) Ca²⁺ mediated by inositol triphosphate receptors (IP₃Rs) maintains cellular bioenergetics, thus suppressing autophagy. We show that t...
Previous studies have shown that small interfering RNA knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) stimulate autophagy. We have investigated autophagy in chicken DT40 cell lines containing targeted deletions of all three IP(3)R isoforms (triple knock-out (TKO) cells). Using gel shifts of microtubule-associated protein 1 light chain 3 as a marker ...
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Leydig cells are responsible for the synthesis and secretion of testosterone, processes controlled by luteinizing hormone (LH). Binding of LH to a G protein-coupled receptor in the plasma membrane results in an increase in cAMP and in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here we show, using immunofluorescence, that Leydig cells express ryanodine receptors (RyRs) and inositol 1,4,5-...
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