Ionic gelation is among the simplest processes for development of chitosan nanoparticles reported so far in literature. Its one-shot synthesis process conjunction with mild reaction conditions required are main causes its success. In this work, we sought to optimize a set physical parameters associated ionic at two different pH values. Following that, NPs’ freeze-drying and long-term storage st...

Objective: The purpose of this study was to determine the optimum formula diltiazem HCl-loaded chitosan nanoparticles due variations in speed and duration stirring evaluating release kinetics vitro using DDSolver.
 Methods: method used prepare is ionic gelation. gelation involves an cross-linking between cations on backbone anion, such as sodium tripolyphosphate (Na TPP). 
 Results: S...

BACKGROUND Superabsorbent hydrogels show a large potential in a wide array of applications due to their unique properties. Carboxymethylcellulose (CMC) is a commercially available water-soluble cellulose derivative of major interest in the hydrogel synthesis. High-energy irradiation allows the chemical crosslinking without the use of crosslinking agents, while the introduction of other natural ...

OBJECTIVE Complexation was investigated as an approach to enhance the entrapment of the cationic neurotherapeutic drug, galantamine hydrobromide (GH) into cationic chitosan nanoparticles (CS-NPs) for Alzheimer's disease management intranasally. Biodegradable CS-NPs were selected due to their low production cost and simple preparation. The effects of complexation on CS-NPs physicochemical proper...

The chitosan nanoparticles used widely as a drug delivery systems recently. In the present study the Echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. The nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. The particles were spherical in shape and th...

Caseinate dissolved in different ionic milieus was used as model substrate for cross-linking by microbial transglutaminase and subsequent acid-induced gelation. The study follows up on previous research, where the molecular properties of cross-linked casein nanoparticles were linked to certain rheological characteristics acid gels (Raak et al., 2019, Food Hydrocoll 86:43–49), presents additiona...

Abstract This study aimed to produce pectin and alginate microparticles by ionic gelation coated with different concentrations of bovine blood egg white protein in their natural state. The were characterized, physical resistance morphology evaluated, as well the released during vitro gastrointestinal simulation. highest adsorption (65.47%) was shown (10%), regardless type concentration used. Li...