Improving oral bioavailability of drugs given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. To address this encumbrance, ionotropic gelation technique has attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by engineering spherical agglomerates. Spherical beads...

The viscoelastic properties of a binary mixture of a mesogenic side-chain block copolymer in a low molecular weight nematic liquid crystal are studied for mass concentrations ranging from the diluted regime up to a liquid crystalline gel state at about 3%. In the gel state, the system does not flow, exhibits a polydomain structure on a microscopic level, and strongly scatters light. Below the g...

Purpose: The aim of the present study was to formulate and evaluate miconazole nitrate containing thermosensitive bioadhesive gel for vaginal drug delivery to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginal candidiasis. Method: Here miconazole nitrate (1%) was formulated as a vaginal gel using thermosensitive polymer, pluronic F127 (20%) along with bioa...

Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understanding of the gelation process is fundamentally important. However, current stud...

Alginate films with different degrees of crosslinking obtained by internal and external gelation method and alginate films incorporated with oregano essential oil were prepared. The effect of mechanism of gelation and the incorporation of oregano essential oil on their optical, mechanical, antibacterial, microstructural and water vapor barrier properties were evaluated. The films subjected to e...

The mechanism by which native silk feedstocks are converted to solid fibres in nature has attracted much interest. To address this question, the present work used rheology to investigate the gelation of Bombyx mori native silk feedstock. Exceeding a critical shear stress appeared to be more important than shear rate, during flow-induced initiation. Compositional changes (salts, pH etc.,) were n...

In this paper, polyacrylamide/chromium acetate gel polymer system was prepared as water shut-off system to control water production in one of the Iranian oil reservoirs condition. Effect of various parameters such as temperature (90 °C) and water formation from view point of salinity and divalent cations, was evaluated on the gelation kinetic and gel strength using bottle testing method. Th...

A self-consistent field theory is developed for polymers that are capable of binding small ionic molecules (adsorbates). The polymer-ionic molecule association is described by Ising-like binding variables, C(i) ((a))(kDelta)(=0 or 1), whose average determines the number of adsorbed molecules, n(BI). Polymer gelation can occur through polymer-ionic molecule complexation in our model. For polymer...

BACKGROUND This work investigates a general method for producing alginate gel matrices using an internal mode of gelation that depends solely on soluble alginate and alginate/gelling ion particles. The method involves the formulation of two-component kits comprised of soluble alginate and insoluble alginate/gelling ion particles. Gelling kinetics, elastic and Young's moduli were investigated fo...