Introduction: This study aimed to investigate the influence of neglect and the effect of Prism Adaptation (PA) combined with continuous Theta-Burst Transcranial Magnetic Stimulation (cTBS) on the art constructive errors of painting rehabilitation of stroke patients with neglect. Methods: Fourteen patients with neglect and art constructive errors of painting secondary to stroke were randomly as...

The question we address here is whether the invasive presurgical brain mapping approaches of direct cortical stimulation and of the Wada procedure can be replaced by noninvasive functional neuroimaging methods (functional magnetic resonance imaging [fMRI], magnetoencephalography [MEG], transcranial magnetic stimulation and [TMS]). First, we outline the reasons for contemplating such a replaceme...

Fibromyalgia (FM) is one of the most difficult chronic pain syndromes to treat, affecting 3% to 5% of the world population [1,2]. It is characterized by musculoskeletal pain and muscle tenderness, accompanied by depression, sleep disorders, fatigue [3], cognitive and mood disturbances, and decreased physical function [4], which leads to a decreased quality of life. Although FM is well studied, ...

BackgroundWidespread demyelination in the central nervous system can lead to progressive sensorimotor impairments following multiple sclerosis, with compromised postural stability during standing being a common consequence. As such, clinical strategies are needed improve sclerosis. The objective of this study was therefore investigate effect non-invasive transcutaneous spinal stimulation on upr...

Our experiences can blind us. Once we have learned to solve problems by one method, we often have difficulties in generating solutions involving a different kind of insight. Yet there is evidence that people with brain lesions are sometimes more resistant to this so-called mental set effect. This inspired us to investigate whether the mental set effect can be reduced by non-invasive brain stimu...

Biomedical enhancement refers to the use of biomedical interventions to improve capacities beyond normal, rather than to treat deficiencies due to diseases. Enhancement can target physical or cognitive capacities, but also complex human behaviors such as morality. However, the complexity of normal moral behavior makes it unlikely that morality is a single capacity that can be deficient or enhan...

The flexible integration of segregated neural processes is essential to healthy brain function. Advances in neuroimaging techniques have revealed that psychiatric and neurological disorders are characterized by anomalies in the dynamic integration of widespread neural populations. Re-establishing optimal neural activity is an important component of the treatment of such disorders. Non-invasive ...

Occipital stroke often leads to visual field loss, for which no effective treatment exists. Little is known about the potential of non-invasive electric current stimulation to ameliorate visual functions in patients suffering from unilateral occipital stroke. One reason is the traditional thinking that visual field loss after brain lesions is permanent. Since evidence is available documenting v...

Neurologic conditions such as stroke, traumatic brain injury, tumors, and degenerative diseases are often associated with dramatic impairments in brain function. Converging evidence in the fields of clinical neurorehabilitation and cognitive neuroscience has revealed that functional recovery after brain injury depends largely on compensatory plastic changes in remaining neural structures. Thus,...

BACKGROUND There is increasing interest in the use of non-invasive brain stimulation to characterize and potentially treat essential tremor (ET). Studies have used a variety of stimulation coils, paradigms, and target locations to make these observations. We reviewed the literature to compare prior studies and to evaluate the rationale and the methods used in these studies. METHODS We perform...