PURPOSE Cervical cancer is the leading cause of cancer-related morbidity and mortality in women in Tanzania. Any impact of the HIV/AIDS epidemic on cervical precancerous lesions and invasive cervical cancer has a significant implication, as for any public health concern, especially in an area such as the Morogoro region in Tanzania, which has one of the highest rates of cervical cancer in the w...

A study was made of all cervical cancer cases that were entered in Costa Rica's National Register of Tumors for the period 1980-1983. The country's average rates of invasive and in situ cervical cancers in these years were 33.6 and 36.3 cases per 100,000 women, respectively. The incidence of invasive cases varied notably in different geographic regions. The approximate cumulative risk of develo...

It has now been established that infection with human papillomavirus (HPV) is necessary for the development of most cervical cancers. HPV is not sufficient for the development of cancer. Other exposures or host factors are necessary for cancer to occur. As part of an ongoing, population-based case-control study of invasive cervical cancer, we investigated the role of cigarette smoking, oral con...

Persistent infection with high-risk types of human papillomavirus(HPV) is known to cause cervical cancer; however, additional genetic and epigenetic alterations are required for progression from precancerous disease to invasive cancer. DNA methylation is an early and frequent molecular alteration in cervical carcinogenesis. In this review, we summarize DNA methylation within the HPV genome and ...

Cervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of ...

In Osijek-Baranja County, there was a rise in the number of non-invasive and fall of invasive cervical cancer in the period 2000-2008, but cervical cancer still represents an important public health problem in Osijek-Baranja County. Cervical cancer in 2008 was the ninth female cancer site and represents 3.5% of all malignant diseases in women. In the same year it was also at the ninth place of ...

background: this research was accomplished to evaluate the ihc expression of p16 (ink4a) and ck17 in low grade cervical intraepithelial lesions (lsil), high grade cervical intraepithelial lesions (hsil) and invasive cervical carcinomas and to assess their correlation to hpv (16e6+18e6). methods: the study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were ...

Comments This project has been funded in whole or in part with federal funds from the Summary and Key Points 1. Development of cervical cancer can be tracked as it progresses from cervical intraepithelial neoplasia to cervical carcinoma in situ to invasive cervical cancer. 2. Human papillomavirus infection is central to the development of all cervical cancers. 3. Most cervical cancers are squam...

BACKGROUND Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention. METHODS We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and inva...

Before 1991, Australianwomen underwent opportunistic screening for cervical cancer, usually annually. From 1991, a national, coordinated approach was implemented, the National Cervical Screening Program (NCSP), which included Pap tests (cervical smears) for women aged 18e70 years every 2 years. This approach has resulted in a significant reduction — nearly 50% — in the incidence of cervical can...